• Publications
  • Influence
Spinosad – a case study: an example from a natural products discovery programme
The discovery and characterization of the soil actinomycete, Saccharopolyspora spinosa, and the insecticidal metabolite spinosad is presented as a case history of a successful project emerging from aExpand
IRAC: Mode of action classification and insecticide resistance management.
  • T. Sparks, R. Nauen
  • Computer Science, Medicine
  • Pesticide biochemistry and physiology
  • 1 June 2015
Diversity is the spice of resistance management by chemical means and thus it provides an approach to IRM providing a straightforward means to identify potential rotation/alternation options. Expand
Resistance and cross-resistance to the spinosyns – A review and analysis
While resistance and cross-resistance to the spinosyns does occur, it is appears to be more limited in impact than might be implied from the large body of literature on the subject. Expand
Evolution of Insect Resistance to Insecticides: A Reevaluation of the Roles of Physiology and Behavior
An intensified study of the actual extent and potential impact of behavioral resistance is suggested, and a model is proposed which recognizes the fundamental continuity of behavior and physiology and posits that the degree of exclusivity of any resistance mechanism is proportional to the resistive ability of that mechanism. Expand
Discovery and characterization of sulfoxaflor, a novel insecticide targeting sap-feeding pests.
Available data are consistent with sulfoxaflor acting via the insect nicotinic receptor in a complex manner, and reflect the unique structure of the sulfoximines compared with neonicotinoids. Expand
Biological Activity of the Spinosyns, New Fermentation Derived Insect Control Agents, on Tobacco Budworm (Lepidoptera: Noctuidae) Larvae
Spinosyn A demonstrates that natural products can provide efficacy against pest lepidopterous larvae, such as H.. virescens, that is on par with that observed for some of the most active synthetic insect control agents, including many pyrethroids. Expand
Natural products as insecticides: the biology, biochemistry and quantitative structure-activity relationships of spinosyns and spinosoids.
Artificial neural network-based quantitative structure activity relationship (QSAR) studies for the spinosyns suggested that modification of the 2',3',4'-tri-O-methylrhamnosyl moiety could improve activity and several spinosoids incorporating these modifications exhibited markedly improved lepidopteran activity compared to spinosad. Expand
Insecticide discovery: an evaluation and analysis.
  • T. Sparks
  • Business, Medicine
  • Pesticide biochemistry and physiology
  • 1 September 2013
An analysis of the time required for the discovery, or more correctly the building process, for a wide range of insecticides developed during the last 60 years is provided. Expand
Natural products for pest control: an analysis of their role, value and future.
An attempt is made to answer questions regarding the existence of an NP model for existing classes of pesticides and what is needed for the discovery of new NPs and NP models for pest control agents. Expand
Novel nicotinic action of the sulfoximine insecticide sulfoxaflor.
The nature of the interaction of sulfoxaflor with nAChRs apparently differs from that of IMI and other neonicotinoids, and when coupled with other known characteristics, indicate that sulf oxaflor represents a significant new insecticide option for the control of sap-feeding insects. Expand