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Turbulent flow energy for aerosolization of powder particles
The process of re-entrainment and re-dispersion of powder particles is studied both theoretically and experimentally in order to discuss the possibilities of improvement of the quality of aerosol… Expand
Mechanims of aerosol particle deposition in the Oro-pharynx under non-steady airflow.
Comparison of experimental and computational results of aerosol deposition in the oro-pharyngeal cast of human published recently (Sosnowski TR, Moskal A, Gradoń L. (2006) Inhal Toxicol; 18: 773-780)… Expand
Formation of particles for dry powder inhalers
Abstract Inhalation therapy is widely employed to deliver drugs to the respiratory epithelium, predominantly for the treatment of local disorders. Recently aerosol therapy has become an attractive… Expand
Short- and mid-term adsorption behaviour of Quillaja Bark Saponin and its mixtures with lysozyme
Abstract The short- and mid-term adsorption kinetics of Quillaja Bark Saponin (QBS) biosurfactant at water–air interface was studied using a maximum bubble pressure and drop shape analysis… Expand
Influence of Insoluble Aerosol Deposits on the Surface Activity of the Pulmonary Surfactant: A Possible Mechanism of Alveolar Clearance Retardation?
- T. Sosnowski
- 1 January 2000
Pulmonary surfactant is believed to be involved in the alveolar clearance both due to its direct influence on the flow of the liquid alveolar hypophase and due to the stimulating effect on the… Expand
Aerosolized albuterol sulfate delivery under neonatal ventilatory conditions: in vitro evaluation of a novel ventilator circuit patient interface connector.
- J. Mazela, Krzysztof Chmura, +7 authors M. Keszler
- Journal of aerosol medicine and pulmonary drug…
BACKGROUND Aerosolized medications that have been used in infants receiving ventilatory support have not been shown to be effective clinically among the smallest patients. The aim of this study was… Expand
Deposition of Fractal-Like Aerosol Aggregates in a Model of Human Nasal Cavity
- A. Moskal, Ł. Makowski, T. Sosnowski, L. Gradón
- Chemistry, Medicine
- Inhalation toxicology
- 1 January 2006
Toxicity of diesel exhaust is related to the inhalation of nano-sized fractal-like aerosol aggregates. Their complex behavior (in comparison to spherical particles) should be taken into account in… Expand
Spraying of Cell Colloids in Medical Atomizers
Aerosols are conveniently used for delivery of medicines to the human body. The most common application is inhalation of anti-asthmatic or anti-inflammatory drugs, nevertheless the spectrum of… Expand
Computational fluid dynamics (CFD) and direct visualization studies of aerosol release from two cyclohaler-type dry powder inhalers
Aerosol flow pattern and emission obtained in two variants of aerolizer/cyclohaler DPI was modeled using CFD at the standard airflow rate of 100 L/min. Airflow was analyzed with k-e turbulence model… Expand
Alteration of surface properties of dipalmitoyl phosphatidylcholine by benzo[a]pyrene: a model of pulmonary effects of diesel exhaust inhalation.
- T. Sosnowski, Michał Koliński, L. Gradón
- Chemistry, Medicine
- Journal of biomedical nanotechnology
- 1 October 2012
Effects of benzo[a]pyrene (BaP) on the surface properties of dipalmitoyl phosphatidylcholine (DPPC) being the basic component of pulmonary surfactant and lipid membranes were studied experimentally… Expand