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Optical Image-guided Surgery—Where Do We Stand?
The various techniques, contrast agents, and camera systems that are currently used for image-guided surgery are reviewed and an overview of the wide range of molecular contrast agents targeting specific hallmarks of cancer is provided.
Optical Image-Guided Cancer Surgery: Challenges and Limitations
Although there are limitations to the intrinsic capacity of the technique, when practical and technical surgical possibilities are considered, optical imaging can be a very powerful intraoperative tool in guiding the future oncologic surgeon toward radical resection and optimal clinical results.
‘In vivo’ optical approaches to angiogenesis imaging
Various bioluminescent and fluorescent gene reporter models and probes are described that can be used to specifically image and quantify neovascularization or the angiogenic process itself.
EGFR targeted nanobody–photosensitizer conjugates for photodynamic therapy in a pre-clinical model of head and neck cancer
Intraoperative fluorescence delineation of head and neck cancer with a fluorescent Anti‐epidermal growth factor receptor nanobody
The feasibility for clinical translation of an epidermal growth factor receptor (EGFR)‐targeting nanobody for intraoperative imaging and resection of orthotopic tongue tumors and cervical lymph node metastases in a mouse model is explored.
Effect of PLGA NP size on efficiency to target traumatic brain injury.
In vivo quantification of the scattering properties of tissue using multi-diameter single fiber reflectance spectroscopy
The potential of using light scattering spectroscopy to optically characterize tissue in vivo is shown and the wavelength-dependent slope of μs′(λ) (scattering power) is significantly higher for tongue and skin than for oral cancer and liver.
Dual-Wavelength Imaging of Tumor Progression by Activatable and Targeting Near-Infrared Fluorescent Probes in a Bioluminescent Breast Cancer Model
Dual-wavelength FLI is a feasible approach to simultaneously detect different features of one tumor and to follow tumor progression with appropriate specificity and sensitivity and may open up new perspectives for the detection of tumors and metastases in various experimental models and could also have clinical applications, such as image-guided surgery.
Towards a Successful Clinical Implementation of Fluorescence-Guided Surgery
A main driving conclusion remains that intraoperative imaging has great clinical potential and that many of the solutions required are best addressed with the community working together to optimally promote and accelerate the clinical implementation of fluorescence imaging towards improving surgical procedures.
Pre-clinical Evaluation of a Cyanine-Based SPECT Probe for Multimodal Tumor Necrosis Imaging
- M. Stammes, Vicky T. Knol-Blankevoort, C. Löwik
- Biology, ChemistryMolecular Imaging and Biology
- 8 June 2016
The radiotracer [111In]DTPA-HQ4 possessed strong and selective necrosis avidity in vitro and in various mouse models of tumor necrosis in vivo, indicating its potential to be clinically applied for diagnostic purposes and to monitor anti-cancer treatment efficacy.