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Revival of CD8+ Treg-mediated suppression.
Despite their first recognition almost 40 years ago, CD8(+) 'suppressor' T cells remain poorly characterized. Recent studies of these lymphocytes, now popularly referred to as regulatory CD8(+) TExpand
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Involvement of Secretory and Endosomal Compartments in Presentation of an Exogenous Self-Glycolipid to Type II NKT Cells1
Natural Killer T (NKT) cells recognize both self and foreign lipid Ags presented by CD1 molecules. Although presentation of the marine sponge-derived lipid αGalCer to type I NKT cells has been wellExpand
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Enhanced presentation of MHC class Ia, Ib and class II-restricted peptides encapsulated in biodegradable nanoparticles: a promising strategy for tumor immunotherapy
BackgroundMany peptide-based cancer vaccines have been tested in clinical trials with a limited success, mostly due to difficulties associated with peptide stability and delivery, resulting inExpand
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Dendritic Cells Use Endocytic Pathway for Cross-Priming Class Ib MHC-Restricted CD8αα+TCRαβ+ T Cells with Regulatory Properties1
Understanding the mechanisms leading to effective priming of lymphocytes with regulatory properties is crucial for the manipulation of immune responses. CD8αα+TCRαβ+ T cells are a special subset ofExpand
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Contribution of TCR Signaling Strength to CD8+ T Cell Peripheral Tolerance Mechanisms
Peripheral tolerance mechanisms are in place to prevent T cells from mediating aberrant immune responses directed against self and environmental Ags. Mechanisms involved in the induction ofExpand
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CD8α+ dendritic cells prime TCR‐peptide‐reactive regulatory CD4+FOXP3− T cells
CD4+ T cells with immune regulatory function can be either FOXP3+ or FOXP3−. We have previously shown that priming of naturally occurring TCR‐peptide‐reactive CD4+FOXP3− Treg specifically controlsExpand
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Allergen peptide immunotherapy in humans inhibits allergen-induced proliferation of CD4+ T cells but does not affect suppressive activity of CD4+CD25+ T cells
Abstract Rationale Our group has previously described immunotherapy using short peptides derived from the major cat allergen Fel d 1, to target CD4+ T cell activation without cross linking IgE. WeExpand
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Immune Suppression by a Novel Population of CD8ββ+TCRββ+ Regulatory T cells
Peripheral tolerance mechanisms involve CD4+CD25+FoxP3+ as well as CD8+ Treg populations, each operating in a distinct manner. Here we have focused on immune suppression mediated by a novelExpand
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Peripheral Deletion of CD8 T Cells Requires p38 MAPK in Cross-Presenting Dendritic Cells
Peripheral tolerance mechanisms exist to prevent autoimmune destruction by self-reactive T cells that escape thymic deletion. Dominant tolerance imposed by CD4+Foxp3+ T regulatory cells can activelyExpand