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Do Novel Antipsychotics Have Similar Pharmacological Characteristics? A Review of the Evidence
The pharmacological properties of the novel antipsychotic drugs (APDs) risperidone, sertindole, olanzapine, quetiapine, ziprasidone, remoxipride, and amperozide are reviewed and compared withExpand
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Reversal of PCP-induced learning and memory deficits in the Morris’ water maze by sertindole and other antipsychotics
RationalIn humans, the N-methyl-d-aspartate antagonist phencyclidine (PCP) induces behavioral changes that mimic schizophrenia symptoms, including positive and negative symptoms as well as cognitiveExpand
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Differential effect of antipsychotics on place navigation of rats in the Morris water maze
A group of novel neuroleptics (e.g. olanzapine, seroquel, sertindole and ziprasidone) and already marketed compounds (e.g. clozapine, haloperidol and risperidone) were tested for acute effect onExpand
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Electrophysiological profile of the new atypical neuroleptic, sertindole, on midbrain dopamine neurones in rats: Acute and repeated treatment
Sertindole (Lundbeck code No. Lu 23‐174) (1‐[2‐[4‐[5‐chloro‐1‐(4‐fluorophenyl)‐1H‐indol‐3‐yl]‐1‐piperidinyl]ethyl]‐2‐ imidazolidinone) is a new potential neuroleptic compound.
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Neurochemical and in vivo pharmacological profile of sertindole, a limbic‐selective neuroleptic compound
Sertindole (5‐chloro‐1‐(4‐fluorophenyl)‐3‐[1‐[2‐(2‐imidazolidinon‐1‐yl)ethyl]‐4‐Piperidyl]‐1H‐indole) is a new neuroleptic with a very high selectivity for dopamine (DA) neurones in the ventralExpand
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Differential effects of repeated administration of novel antipsychotic drugs on the activity of midbrain dopamine neurons in the rat.
  • T. Skarsfeldt
  • Medicine
  • European journal of pharmacology
  • 15 August 1995
Five potential antipsychotics (i.e. risperidone, olanzapine, seroquel, ziprasidone and amperozide) were given daily for 21 days to rats and the effect on the number of spontaneously active dopamineExpand
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Differential effects after repeated treatment with haloperidol, clozapine, thioridazine and tefludazine on SNC and VTA dopamine neurones in rats.
The effects of repeated treatment (21 days) with different antipsychotic compounds (haloperidol, clozapine, thioridazine and tefludazine) on dopamine (DA) neurones in substantia nigra pars compactaExpand
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Correlation between level of (n - 3) polyunsaturated fatty acids in brain phospholipids and learning ability in rats. A multiple generation study.
The effects of dietary n - 3 polyunsaturated fatty acids (PUFAs) on major brain phospholipids were examined in the rat throughout four generations. Dietary fats were: a seal oil (22:6(n - 3) locatedExpand
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Effect of chronic treatment with SCH 23390 and haloperidol on spontaneous activity of dopamine neurones in substantia nigra pars compacta (SNC) and ventral tegmental area (VTA) in rats.
  • T. Skarsfeldt
  • Chemistry, Medicine
  • European journal of pharmacology
  • 12 January 1988
The effect of chronic treatment (21 days s.c.) with SCH 23390 and haloperidol on spontaneously active DA neurones in substantia nigra pars compacta (SNC) and ventral tegmental area (VTA) was studiedExpand
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