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Radical Scavenging and Antioxidant Activity of Ethanolic Extract of Mollugo nudicaulis by Invitro Assays
ABSTRACT Revised: 22-12-2010 Submitted: 23-10-2010 Accepted: 27-4-2011 INTRODUCTION Reactive oxygen species (ROS) generated in cells, are fundamental in modulating various physiological functions andExpand
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In vitro Antioxidant and Antibacterial Activities of Methanol Extract of Kyllinga nemoralis
The present study was designed to evaluate the antioxidant and antibacterial activity of methanol extract of Kyllinga nemoralis. Six different in vitro antioxidant assays includingExpand
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Exploring the binding properties of agonists interacting with human TGR5 using structural modeling, molecular docking and dynamics simulations
TGR5, a G-protein coupled receptor, acts as a promising target for the treatment of diabetes, obesity and metabolic syndromes. Understanding the activation of TGR5, the structural conformation andExpand
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Identification of potential dual agonists of FXR and TGR5 using e-pharmacophore based virtual screening.
Farnesoid X receptor and Takeda G-protein-coupled receptor-5 are well known bile acid receptors and act as promising targets for the drug development and treatment of diabetes. Agonists of both theExpand
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The present study was designed to investigate the in alloxan (120 mg/kg b.wt) induced diabetic rats. The ethanolic extract of the whole plant of Mollugo nudicaulis (200mg/kg) administered orally toExpand
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Insecticide-resistance mechanism of Plutella xylostella (L.) associated with amino acid substitutions in acetylcholinesterase-1: A molecular docking and molecular dynamics investigation
AChE1 is a vital enzyme involved in neurotransmission and represents an attractive insecticide-target for organophosphates and carbamates in Plutella xylostella (Linneaus), an important pest of cruciferous crops worldwide. Expand
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Exploring the resistance-developing mutations on Ryanodine receptor in diamondback moth and binding mechanism of its activators using computational study
Insect Ryanodine receptor (RyR) is an intracellular calcium release channels that play a key role in calcium signaling in numerous cell types. Targeting Ryanodine receptor is considered as efficientExpand
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Pharmacophore modeling, 3D-QSAR and molecular docking studies of benzimidazole derivatives as potential FXR agonists
Abstract Farnesoid X receptor (FXR) is a potential therapeutic target for the treatment of diabetes mellitus. Atom-based three-dimensional quantitative structure activity relationship (3D-QSAR)Expand
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Tuberculosis is the world’s second most common cause of death from infectious disease, after HIV/ AIDS. The disease is usually chronic with varying clinical manifestation, remains one of the biggestExpand
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Protective effect of Mollugo nudicaulis Lam. on acute liver injury induced by perchloroethylene in experimental rats.
OBJECTIVE To evaluate the protective effect of ethanol extract of Mollugo nudicaulis (M. nudicaulis) against perchloroethylene-induced hepatotoxicity. METHODS The hepatoprotective activity of theExpand
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