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- Publications
- Influence
Radical Scavenging and Antioxidant Activity of Ethanolic Extract of Mollugo nudicaulis by Invitro Assays
- S. Rajamanikandan, T. Sindhu, D. Durgapriya, D. Sophia, P. Ragavendran, Velliyur Kanniappan Gopalakrishnan
- Chemistry
- 2011
ABSTRACT Revised: 22-12-2010 Submitted: 23-10-2010 Accepted: 27-4-2011 INTRODUCTION Reactive oxygen species (ROS) generated in cells, are fundamental in modulating various physiological functions and… Expand
- 40
- 1
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In vitro Antioxidant and Antibacterial Activities of Methanol Extract of Kyllinga nemoralis
- T. Sindhu, S. Rajamanikandan, P. Srinivasan
- Chemistry, Medicine
- Indian journal of pharmaceutical sciences
- 1 March 2014
The present study was designed to evaluate the antioxidant and antibacterial activity of methanol extract of Kyllinga nemoralis. Six different in vitro antioxidant assays including… Expand
Exploring the binding properties of agonists interacting with human TGR5 using structural modeling, molecular docking and dynamics simulations
- T. Sindhu, P. Srinivasan
- Chemistry
- 28 January 2015
TGR5, a G-protein coupled receptor, acts as a promising target for the treatment of diabetes, obesity and metabolic syndromes. Understanding the activation of TGR5, the structural conformation and… Expand
Identification of potential dual agonists of FXR and TGR5 using e-pharmacophore based virtual screening.
- T. Sindhu, P. Srinivasan
- Chemistry, Medicine
- Molecular bioSystems
- 21 April 2015
Farnesoid X receptor and Takeda G-protein-coupled receptor-5 are well known bile acid receptors and act as promising targets for the drug development and treatment of diabetes. Agonists of both the… Expand
ANTIDIABETIC ACTIVITY OF MOLLUGO NUDICAULIS AGAINST ALLOXAN INDUCED DIABETIC RATS
- T. Sindhu, S. Rajamanikandan, +4 authors Velliyur Kanniappan Gopalakrishnan
- Chemistry
- 2010
The present study was designed to investigate the in alloxan (120 mg/kg b.wt) induced diabetic rats. The ethanolic extract of the whole plant of Mollugo nudicaulis (200mg/kg) administered orally to… Expand
- 14
Insecticide-resistance mechanism of Plutella xylostella (L.) associated with amino acid substitutions in acetylcholinesterase-1: A molecular docking and molecular dynamics investigation
- T. Sindhu, T. Venkatesan, +4 authors A. Rai
- Chemistry, Medicine
- Comput. Biol. Chem.
- 1 December 2018
TLDR
Exploring the resistance-developing mutations on Ryanodine receptor in diamondback moth and binding mechanism of its activators using computational study
- T. Sindhu, T. Venkatesan, Gandhi R. Gracy, S. K. Jalali, A. Rai
- Chemistry
- 15 May 2017
Insect Ryanodine receptor (RyR) is an intracellular calcium release channels that play a key role in calcium signaling in numerous cell types. Targeting Ryanodine receptor is considered as efficient… Expand
Pharmacophore modeling, 3D-QSAR and molecular docking studies of benzimidazole derivatives as potential FXR agonists
- T. Sindhu, P. Srinivasan
- Chemistry, Medicine
- Journal of receptor and signal transduction…
- 29 July 2014
Abstract Farnesoid X receptor (FXR) is a potential therapeutic target for the treatment of diabetes mellitus. Atom-based three-dimensional quantitative structure activity relationship (3D-QSAR)… Expand
ANTI MYCOBACTERIAL ACTIVITY OF 1, 4-OXAZINES AND 1, 4- THIAZINES
- T. Sindhu, D. Paul, M. Chandran, A. Bhat, K. Krishnakumar, J. Sindhu.T.
- Chemistry
- 2014
Tuberculosis is the world’s second most common cause of death from infectious disease, after HIV/ AIDS. The disease is usually chronic with varying clinical manifestation, remains one of the biggest… Expand
- 3
Protective effect of Mollugo nudicaulis Lam. on acute liver injury induced by perchloroethylene in experimental rats.
- S. Rajamanikandan, T. Sindhu, D. Durgapriya, D. Sophia, P. Ragavendran, Velliyur Kanniappan Gopalakrishnan
- Chemistry, Medicine
- Asian Pacific journal of tropical medicine
- 1 November 2012
OBJECTIVE
To evaluate the protective effect of ethanol extract of Mollugo nudicaulis (M. nudicaulis) against perchloroethylene-induced hepatotoxicity.
METHODS
The hepatoprotective activity of the… Expand