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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
There continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes, so it is important to update guidelines for monitoring autophagic activity in different organisms.
NLRP3 inflammasome: From a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases
Interleukin 21-induced granzyme B-expressing B cells infiltrate tumors and regulate T cells.
These findings establish the existence of human B cells with a regulatory phenotype in solid tumor infiltrates, where they may contribute to the suppression of antitumor immune responses and stimulate novel diagnostic and cell therapeutic approaches to better manage human cancer as well as autoimmune and graft-versus-host pathologies.
Differential uptake of functionalized polystyrene nanoparticles by human macrophages and a monocytic cell line.
The data show that the amount of internalized nanoparticles, the uptake kinetics, and its mechanism may differ considerably between primary cells and a related tumor cell line, whether differentiated or not, and that particle uptake by these cells is critically dependent on particle opsonization by serum proteins.
Differential expression and regulation of protease-activated receptors in human peripheral monocytes and monocyte-derived antigen-presenting cells.
- R. Colognato, J. Slupsky, M. Jendrach, L. Burýšek, T. Syrovets, T. Simmet
- Biology, MedicineBlood
- 1 October 2003
It is demonstrated that differentiation of human monocytes is associated with differential expression of functionally active PARs that mediate distinct regulatory functions in inflammation and atherogenesis.
Plasmin as a proinflammatory cell activator
Excessive activation of plasmin in chronic inflammatory or autoimmune diseases might exacerbate the activation of inflammatory cells and the pathogenesis of the disease.
The effect of carboxydextran-coated superparamagnetic iron oxide nanoparticles on c-Jun N-terminal kinase-mediated apoptosis in human macrophages.
Acetyl-boswellic acids are novel catalytic inhibitors of human topoisomerases I and IIalpha.
- T. Syrovets, B. Büchele, E. Gedig, J. Slupsky, T. Simmet
- Biology, ChemistryMolecular pharmacology
- 1 July 2000
This work proposes that acetyl-BA inhibit topoisomerases I and IIalpha through competition with DNA for binding to the enzyme, and demonstrates that these compounds are a unique class of dual catalytic inhibitors of human topoisomersases I or IIalpha.
Amino‐functionalized polystyrene nanoparticles activate the NLRP3 inflammasome in human macrophages
It is shown that PS‐NH2 but not PS‐COOH or PS induce activation of specifically the NLRP3 inflammasome, which may induce proinflammatory activation of human macrophages, an effect that can be antagonized by radical scavengers.
Effects of the endogeneous cannabinoid, anandamide, on neuronal activity in rat hippocampal slices
Cannabin receptors of the CB1 type as well as their endogeneous ligand, anandamide, are involved in the control of neuronal excitability, thus reducing excitatory neurotransmission at a presynaptic site, a mechanism which might be involved inThe prevention of excessive excitability leading to epileptiform activity.