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Nitric Oxide Inhibitors Ameliorate Indomethacin-Induced Enteropathy in Rats
The data suggest that NO derived from iNOS may be a key factor in the pathogenesis of acute INDO-induced enteropathy in rats. Expand
Expression of inducible nitric oxide synthase (iNOS) in rat intestinal mucosa by indomethacin
INDO treatment increases iNOS expression in small intestinal mucosa as early as 3 and 4 days with concomitant increased ulcer length and MPO activity, suggesting that NO produced by iNos may contribute to the development of ulceration and inflammation in INDOinduced enteropathy. Expand