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Learning enhances adult neurogenesis in the hippocampal formation
- E. Gould, A. Beylin, P. Tanapat, A. Reeves, T. Shors
- Biology, PsychologyNature Neuroscience
- 1 March 1999
It is reported that the number of adult-generated neurons doubles in the rat dentate gyrus in response to training on associative learning tasks that require the hippocampus, which indicates that adult- generated hippocampal neurons are specifically affected by, and potentially involved in, associative memory formation.
Neurogenesis in the adult is involved in the formation of trace memories
- T. Shors, G. Miesegaes, A. Beylin, Mingrui Zhao, T. Rydel, E. Gould
- Biology, PsychologyNature
- 15 March 2001
It is shown that a substantial reduction in the number of newly generated neurons in the adult rat impairs hippocampal-dependent trace conditioning, a task in which an animal must associate stimuli that are separated in time.
Neurogenesis may relate to some but not all types of hippocampal‐dependent learning
The results combined with previous ones suggest that neurogenesis may be associated with the formation of some but not all types of hippocampal‐dependent memories.
Brain-Derived Neurotrophic Factor-Induced Gene Expression Reveals Novel Actions of VGF in Hippocampal Synaptic Plasticity
Increased expression in vitro predicted elevations in vivo: VGF and the IEGs increased after trace eyeblink conditioning, a hippocampal-dependent learning paradigm, which suggested that the VGF neuropeptides may regulate synaptic function.
The Role of the Hippocampus in Trace Conditioning: Temporal Discontinuity or Task Difficulty?
- A. Beylin, C. Gandhi, G. Wood, A. Talk, L. Matzel, T. Shors
- Psychology, BiologyNeurobiology of Learning and Memory
- 1 November 2001
The role of the hippocampus in classical conditioning is not limited to learning about discontiguous events in time and space; rather the structure can become engaged simply as a function of task difficulty.
Neurogenesis in adulthood: a possible role in learning
Sex Differences and Opposite Effects of Stress on Dendritic Spine Density in the Male Versus Female Hippocampus
Males and females have different levels of dendritic spine density in the hippocampus under unstressed conditions, and their neuronal anatomy can respond in opposite directions to the same stressful event.
Associative Memory Formation Increases the Observation of Dendritic Spines in the Hippocampus
It is suggested that the formation and expression of associative memories increase the availability of dendritic spines and the potential for synaptic contact, and is tested whether the acquisition of new memories is associated with changes in the density of dendsrites.
Inescapable versus escapable shock modulates long-term potentiation in the rat hippocampus.
Results provide evidence that controllability modulates plasticity at the cellular-neuronal level and exposure to uncontrollable shock massively impaired LTP relative to exposure to the same amount and regime of controllable shock.
The Neuropeptide VGF Produces Antidepressant-Like Behavioral Effects and Enhances Proliferation in the Hippocampus
Chronic VGF treatment enhances proliferation of hippocampal progenitor cells both in vitro and in vivo with survival up to 21 d, and it is demonstrated that VGF increases the number of dividing cells that express neuronal markers in vitro.