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Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution
TLDR
A draft genome sequence of the red jungle fowl, Gallus gallus, provides a new perspective on vertebrate genome evolution, while also improving the annotation of mammalian genomes.
The HLA genomic loci map: expression, interaction, diversity and disease
TLDR
The degrees and types of HLA super-locus coordinated gene expression profiles and gene variations have yet to be fully elucidated, integrated and defined for the processes involved with normal cellular and tissue physiology, inflammatory and immune responses, and autoimmune and infectious diseases.
Chloroplast-mediated activation of plant immune signalling in Arabidopsis.
TLDR
It is shown that pathogen-associated molecular pattern (PAMP) signals are quickly relayed to chloroplasts and evoke specific Ca(2+) signatures in the stroma, allowing chloroplast-mediated transcriptional reprogramming during plant immune responses.
A nuclear-encoded sigma factor, Arabidopsis SIG6, recognizes sigma-70 type chloroplast promoters and regulates early chloroplast development in cotyledons.
TLDR
Northern and array-based global analyses for plastid transcripts revealed that the transcript levels of most PEP-dependent genes were greatly reduced in the sig6-1 mutant, but that the accumulation of nuclear-encoded RNA polymerase (NEP)-dependent transcripts generally increased.
Allogeneic transplantation of iPS cell-derived cardiomyocytes regenerates primate hearts
TLDR
The data demonstrate that allogeneic iPSC-CM transplantation is sufficient to regenerate the infarcted non-human primate heart; however, further research to control post-transplant arrhythmias is necessary.
Structural dynamics of cereal mitochondrial genomes as revealed by complete nucleotide sequencing of the wheat mitochondrial genome
The application of a new gene-based strategy for sequencing the wheat mitochondrial genome shows its structure to be a 452 528 bp circular molecule, and provides nucleotide-level evidence of
Evidence of en bloc duplication in vertebrate genomes
TLDR
Phylogenetic analysis of 31 genes in the major histocompatibility complex paralogous regions of amphioxus shows that duplications occurred after the divergence of cephalochordates and vertebrates but before the Gnathostomata radiation.
The amphioxus genome illuminates vertebrate origins and cephalochordate biology.
TLDR
The results indicate that the amphioxus genome is elemental to an understanding of the biology and evolution of nonchordate deuterostomes, invertebrate chordates, and vertebrates.
Extended Gene Map Reveals Tripartite Motif, C-Type Lectin, and Ig Superfamily Type Genes within a Subregion of the Chicken MHC-B Affecting Infectious Disease12
TLDR
The MHC-B region gene map is expanded beyond the 92-kb core previously reported for another haplotype revealing the presence of 46 genes within 242 kb in the Red Jungle Fowl haplotype, many of which are similar to genes that define the NK complex in mammals.
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