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Aldehyde oxidase-dependent marked species difference in hepatic metabolism of the sedative-hypnotic, zaleplon, between monkeys and rats.
- K. Kawashima, K. Hosoi, T. Naruke, T. Shiba, M. Kitamura, T. Watabe
- BiologyDrug metabolism and disposition: the biological…
- 1 March 1999
N-Desethyl-Zaleplon was formed in the presence of NADPH by microsomes from the liver of rats and monkeys, and its formation was strongly suggested using various cytochrome P-450 inhibitors to be mediated by a number of cytochrom P- 450 isoforms, such as 3A, 2C, and 2D subfamilies.
Immunological analysis of the phosphorylation state of maize C4-form phosphoenolpyruvate carboxylase with specific antibodies raised against a synthetic phosphorylated peptide.
The results suggest that the regulatory phosphorylation of C4-form PEPC in mature maize plants is controlled not only by a light signal but also by some other metabolic signal(s).
Total synthesis of peptide antibiotic nisin
Identity of a major 3-deoxyglucosone-reducing enzyme with aldehyde reductase in rat liver established by amino acid sequencing and cDNA expression.
Macrophage-stimulating effect of a synthetic muramyl dipeptide and its adjuvant-active and -inactive analogs for the production of T-cell activating monokines.
Induction of human interleukin 1 by bacterial and synthetic lipid A
It is shown that the lipid A component of LPS is active in inducing IL 1 and that the presence of 3‐acyloxyacyl residues is necessary for IL1 induction.
Correlation between the immunoadjuvant activities and pyrogenicities of synthetic N-acetylmuramyl-peptides or -amino acids.
None of the adjuvant-inactive analogues or diastereomers of the above N-acetylmuramyl-dipeptide or related compounds caused any significant febrile response in rabbits, even at a dose of 250 mug per animal.
Arthritis-inducing ability of a synthetic adjuvant, N-acetylmuramyl peptides, and bacterial disaccharide peptides related to different oil vehicles and their composition
It is concluded that one of the minimal essential structures responsible for development of this disease is MDP, although the role of the oil vehicle remained uncertain, and there is no direct correlation between granulona formation and arthritogenicity of MDP.
Purification and cDNA Cloning of Porcine Brain GDP-L-Fuc:N-Acetyl-β-D-Glucosaminide α1→6Fucosyltransferase*
- N. Uozumi, S. Yanagidani, N. Taniguchi
- Biology, ChemistryThe Journal of Biological Chemistry
- 1 November 1996
Northern blotting analyses of rat adult tissues showed that α1-6FucT was highly expressed in brain, and no sequence homology was found with other previously cloned fucosyl transferases, but the enzyme appears to be a type II transmembrane protein like the other glycosyltransferases.
Immunogenicity and antigenicity of synthetic Escherichia coli lipid A
All antisera were found to react with their corresponding homologous antigens coated onto sheep erythrocytes, with titers of up to 2,048, and were comparable to those antisers obtained after immunization with natural lipid A exposed on the bacterial surface after acid hydrolysis.