T. Shepard

Publications171
h-index40
Citations6,302
Highly Influential Citations65
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National toxicology program.
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Familial Addison's disease; case reports of two sisters with corticoid deficiency unassociated with hypoaldosteronism.
Although familial Addison's disease has been previously reported, it is usually associated with hypoparathyroidism or with congenital adrenal hyperplasia. Familial Addison's disease by itself is… Expand
  • 126
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Brain growth in Down syndrome subjects 15 to 22 weeks of gestational age and birth to 60 months.
We have found similarities of skull shape, brain growth and brain maturation in 17 DS and 10 non-DS (control) fetuses, ages 15-22 weeks of gestational age (Group A), and differences in 101 DS and 80… Expand
  • 183
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A selection of candidate compounds for in vitro teratogenesis test validation.
TLDR
The Consensus Workshop on In Vitro Teratogenesis Testing recommended that test validation be facilitated by a listing of agents with defined teratogenicity; subsequently, a panel was convened to review and select agents. Expand
  • 110
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"Proof" of human teratogenicity.
  • 75
  • 3
Chromosomal abnormalities in fetuses with omphalocele. Significance of omphalocele contents.
Twenty‐six consecutive fetuses with a sonographically detectable omphalocele and known karyotype were reviewed to identify risk factors that might be associated with chromosomal abnormalities. Risk… Expand
  • 104
  • 3
Aspirin and acetaminophen use by pregnant women and subsequent child IQ and attention decrements.
In a longitudinal prospective study of 1,529 women pregnant in 1974-1975, aspirin and acetaminophen were the two medications most frequently taken during the first half of pregnancy (46 and 41%,… Expand
  • 81
  • 3
Teratogenicity of Vitamin B6 Deficiency: Omphalocele, Skeletal and Neural Defects, and Splenic Hypoplasia
Vitamin B6 deficiency was induced in pregnant rats with a deficient diet and with 4-deoxypyridoxine, a B6 antagonist. Treated animals developed typical skin changes of B6 deficiency. Fetuses were… Expand
  • 64
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Bowel migration in the normal fetus: US detection.
Ten fetuses underwent ultrasound scanning at 7-10 weeks gestational (postmenstrual) age. In all cases, an echogenic mass measuring 0.5-1.0 cm was demonstrated within the base of the umbilical cord at… Expand
  • 65
  • 2
Normal length of the human fetal gastrointestinal tract.
Little information is available on the normal length of the gastrointestinal tract in fetuses or on factors that may affect its growth. To determine normal growth patterns of the fetal intestine, 58… Expand
  • 32
  • 2