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Effects of triptolide on the expression and activity of NF-κB in synovium of collagen-induced arthritis rats
TLDR
Triptolide may play a protective role in RA via downregulating the expression and activity of NF-κB in synovium through downregulation of immunohistochemistry and electrophoretic mobility shift assay. Expand
Effect of sinomenine on IL-8, IL-6, IL-2 produced by peripheral blood mononuclear cells
SummaryThe effect of Sinomenine on IL-8, IL-6, IL-2 and mIL-2R produced by peripheral blood mononuclear cells was investigated by using cell culture, radioimmunoassay and flow cytometry. It wasExpand
Effect of triptolide on expression of receptor activator of nuclear factor-κB ligand in rat adjuvant induced arthritis
TLDR
TP could inhibit rat adjuvant arthritis bone erosion by suppressing the expression of RANKL through inhibition of TNF-α and IL-1β in peripheral blood mononuclear cells. Expand
A randomized, controlled, single-blind trial of leflunomide in the treatment of rheumatoid arthritis
TLDR
LEF had a good therapeutic effect for RA, especially for refractory RA and had slight side reactions, and could be regarded as a superior immunosuppressive agent used in the treatment of RA and other connective tissue diseases. Expand
Relationship between single nucleotide polymorphism in TNF-α gene promoter region and inibitory effects of triptolide on TNF-α production in peripheral blood mononuclear cells of healthy humans
TLDR
TNF- α gene polymorphism was related to the TNF-α production from triptolide-inhibited PBMC culture in healthy humans, and had no effect on the level of T NF-α from non-G/G genotype PBMC. Expand
Triptolide induces apoptosis of rat synoviocytes in collagen- induced arthritis
TLDR
It is demonstrated that triptolide can induce apoptosis in CIA rats, which may be one of the mechanisms that triPTolide treats the rheumatoid arthritis. Expand
Clinical Observation of Effect of Methotrexate Combined with Zhengqingfengtongning in Treating Active Rheumatoid Arthritis Based on Syndrome Differentiation
TLDR
MTX plus Zhengqingfengtongning treatment is characterized by quick initiating, with stable clinical efficacy and few side effects, and is better than MTX treatment alone, especially suitable for Syndrome of wind dampness stagnation. Expand
Clinical Study of Lingqia Sijun Granule Combined with Chemoth erapy in Treating Gastric Cancer
TLDR
Lingqia Sijun granule combined with chemotherapy can antagonize the side effect caused by c hemotherapy and improve the general condition of the patients, improve the immune function, protect the patients from the suppression of the bone marrow caused by the chemotherapy and lower the blood viscosity. Expand
Study on determination of triptolide in human plasma by HPLC-MS
OBJECTIVE To establish a method for the determination of triptolide in human plasma by HPLC/MS. METHODS Use Thermo-keystone Hypurity C_(18) column (150×(2.1) mm, 5μm);the mobile phase wasExpand