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The antiparasitic drug niclosamide inhibits dengue virus infection by interfering with endosomal acidification independent of mTOR
TLDR
It is demonstrated that niclosamide diminishes viral infection by hindering endosomal acidification and reducing viral dsRNA replication in DENV-infected ICR suckling mice. Expand
A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease.
TLDR
A protocol to use an immunocompetent outbred ICR (Institute of Cancer Research) mouse for investigating the induction of central nervous system (CNS) infection with DENV, followed by the progression of acute viral encephalitis-like disease is presented. Expand
Early dexamethasone treatment exacerbates enterovirus 71 infection in mice.
TLDR
Investigation of Dex treatment on EV71 infection using the murine model found that both long-term and short-term Dex treatment starting from 1 or 3 days postinfection increased the mortality and disease severity of infected mice and demonstrated that Dex treatment has no beneficial effect on EV 71 infection. Expand
Anti‐TNF‐α restricts dengue virus‐induced neuropathy
TLDR
An immunopathogenesis of TNF‐α for mediating DENV‐induced encephalitis‐associated neurotoxicity is demonstrated and it is shown that targeting TNF-α can be used as a strategy against dengueEncephalitis. Expand
Blockade Effects of Anti-Interferon- (IFN-) γ Autoantibodies on IFN-γ-Regulated Antimicrobial Immunity
TLDR
Results show the blockade activity of anti-IFN-γ autoAbs on IFN- γ-mediated antimicrobial immunity in macrophages in patients with adult-onset immunodeficiency. Expand
Senescence in Monocytes Facilitates Dengue Virus Infection by Increasing Infectivity
TLDR
It is demonstrated that a senescent phenotype facilitates dengue virus infection, probably by increasing DC-SIGN expression. Expand
CNS Immune Profiling in a Dengue Virus-Infected Immunocompetent Outbred ICR Mice Strain
TLDR
A CNS immune profile of DENV infection and hypothetical CNS immunity in response toDENV infection is indicated and the time-dependent induction of proinflammatory and NK1.1-associated cytokines in the DENV-infected brains are shown. Expand
NASAL INFECTION WITH THE VIRUS OF JAPANESE B ENCEPHALITIS IN MICE
TLDR
The evidences of present experiment indicated, that the nasal secretions and the hairs innose of mice could filtering out microorganisms, and the possibility to isolate the pure virus-strain from the contaminated materials by nasal instillation has been discussed. Expand
Signaling of Macrophage Inflammatory Protein (MIP)-3β Facilitates Dengue Virus-Induced Microglial Cell Migration
TLDR
It is demonstrated that secreted MIP-3β and its effect on the JNK signaling pathways mediates DENV-induced BV2 microglial cell migration. Expand
Increased TNF-α Initiates Cytoplasmic Vacuolization in Whole Blood Coculture with Dengue Virus
TLDR
The potential hematological damage caused by ex vivo DENV-induced TNF-α was demonstrated, particularly a significant reduction in CD14-positive monocytes as well as CD11c-positive dendritic cells. Expand
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