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Expression Cloning and Characterization of a Novel Multispecific Organic Anion Transporter*
- T. Sekine, N. Watanabe, M. Hosoyamada, Y. Kanai, H. Endou
- Chemistry, Medicine
- The Journal of Biological Chemistry
- 25 July 1997
Numerous drugs and endogenous compounds are efficiently excreted from the renal proximal tubule via carrier-mediated pathways. Transepithelial excretion of organic anions occurs via their… Expand
Molecular Cloning and Characterization of a New Multispecific Organic Anion Transporter from Rat Brain*
- H. Kusuhara, T. Sekine, +6 authors H. Endou
- Chemistry, Medicine
- The Journal of Biological Chemistry
- 7 May 1999
A cDNA encoding the new member of the multispecific organic anion transporter family, OAT3, was isolated by the reverse transcription-polymerase chain reaction cloning method. Degenerate primers were… Expand
Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney.
A cDNA encoding a multispecific organic anion transporter 3 (hOAT3) was isolated from a human kidney cDNA library. The hOAT3 cDNA consisted of 2179 base pairs that encoded a 543-amino-acid residue… Expand
Identification of multispecific organic anion transporter 2 expressed predominantly in the liver
In the present study, we demonstrate that NLT (novel liver‐specific transport protein) is a multispecific organic anion transporter of the liver. The amino acid sequence of NLT shows 42% identity to… Expand
Molecular Cloning and Characterization of Multispecific Organic Anion Transporter 4 Expressed in the Placenta*
- S. H. Cha, T. Sekine, +6 authors H. Endou
- Chemistry, Medicine
- The Journal of Biological Chemistry
- 11 February 2000
A cDNA encoding a novel multispecific organic anion transporter, OAT4, was isolated from a human kidney cDNA library. The OAT4 cDNA consisted of 2210 base pairs that encoded a 550-amino acid residue… Expand
Immunolocalization of multispecific organic anion transporters, OAT1, OAT2, and OAT3, in rat kidney.
- R. Kojima, T. Sekine, M. Kawachi, S. H. Cha, Y. Suzuki, H. Endou
- Biology, Medicine
- Journal of the American Society of Nephrology…
- 1 April 2002
Recently, a family of multispecific organic anion transporters has been identified, and several isoforms have been reported. However, the physiologic and pharmacologic roles of each isoform, except… Expand
Characterization of Methotrexate Transport and Its Drug Interactions with Human Organic Anion Transporters
- M. Takeda, Suparat Khamdang, +5 authors H. Endou
- Chemistry, Medicine
- Journal of Pharmacology and Experimental…
- 1 August 2002
Life-threatening drug interactions are known to occur between methotrexate and nonsteroidal anti-inflammatory drugs (NSAIDs), probenecid, and penicillin G. The purpose of this study was to… Expand
Human organic anion transporters and human organic cation transporters mediate renal antiviral transport.
- M. Takeda, Suparat Khamdang, +6 authors H. Endou
- Chemistry, Medicine
- The Journal of pharmacology and experimental…
- 1 March 2002
Renal excretion is an important elimination pathway for antiviral agents, such as acyclovir (ACV), ganciclovir (GCV), and zidovudine (AZT). The purpose of this study was to elucidate the molecular… Expand
Interaction of human organic anion transporters 2 and 4 with organic anion transport inhibitors.
- A. Enomoto, M. Takeda, +8 authors H. Endou
- Chemistry, Medicine
- The Journal of pharmacology and experimental…
- 1 June 2002
The organic anion transport system is involved in the tubular excretion and reabsorption of various drugs and substances. The purpose of this study was to characterize the effects of various organic… Expand
Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney.
- M. Hosoyamada, T. Sekine, Y. Kanai, H. Endou
- Biology, Medicine
- The American journal of physiology
- 1999
Recently, we isolated the multispecific organic anion transporter (OAT1) from the rat kidney, which plays important roles in the renal elimination of endogenous and exogenous organic anions including… Expand