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Expression Cloning and Characterization of a Novel Multispecific Organic Anion Transporter*
Numerous drugs and endogenous compounds are efficiently excreted from the renal proximal tubule via carrier-mediated pathways. Transepithelial excretion of organic anions occurs via theirExpand
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Molecular Cloning and Characterization of a New Multispecific Organic Anion Transporter from Rat Brain*
A cDNA encoding the new member of the multispecific organic anion transporter family, OAT3, was isolated by the reverse transcription-polymerase chain reaction cloning method. Degenerate primers wereExpand
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Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney.
A cDNA encoding a multispecific organic anion transporter 3 (hOAT3) was isolated from a human kidney cDNA library. The hOAT3 cDNA consisted of 2179 base pairs that encoded a 543-amino-acid residueExpand
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Molecular Cloning and Characterization of Multispecific Organic Anion Transporter 4 Expressed in the Placenta*
A cDNA encoding a novel multispecific organic anion transporter, OAT4, was isolated from a human kidney cDNA library. The OAT4 cDNA consisted of 2210 base pairs that encoded a 550-amino acid residueExpand
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Identification of multispecific organic anion transporter 2 expressed predominantly in the liver
In the present study, we demonstrate that NLT (novel liver‐specific transport protein) is a multispecific organic anion transporter of the liver. The amino acid sequence of NLT shows 42% identity toExpand
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Immunolocalization of multispecific organic anion transporters, OAT1, OAT2, and OAT3, in rat kidney.
Recently, a family of multispecific organic anion transporters has been identified, and several isoforms have been reported. However, the physiologic and pharmacologic roles of each isoform, exceptExpand
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Characterization of Methotrexate Transport and Its Drug Interactions with Human Organic Anion Transporters
Life-threatening drug interactions are known to occur between methotrexate and nonsteroidal anti-inflammatory drugs (NSAIDs), probenecid, and penicillin G. The purpose of this study was toExpand
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Human organic anion transporters and human organic cation transporters mediate renal antiviral transport.
Renal excretion is an important elimination pathway for antiviral agents, such as acyclovir (ACV), ganciclovir (GCV), and zidovudine (AZT). The purpose of this study was to elucidate the molecularExpand
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Interaction of human organic anion transporters 2 and 4 with organic anion transport inhibitors.
The organic anion transport system is involved in the tubular excretion and reabsorption of various drugs and substances. The purpose of this study was to characterize the effects of various organicExpand
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Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney.
Recently, we isolated the multispecific organic anion transporter (OAT1) from the rat kidney, which plays important roles in the renal elimination of endogenous and exogenous organic anions includingExpand
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