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Intratracheal delivery of insulin Absorption from solution and aerosol by rat lung
Abstract In this study, we investigated the dynamics of insulin absorption from the lung with reference to bioavailability. Human insulin in 10 μl of aqueous solution and an insulin aerosol wereExpand
Antihypertensive action of indapamide and review of pharmacology and toxicology
SummaryA series of studies was carried out to investigate the pharmacology and toxicology of indapamide. Indapamide decreased contractile responses of a number of different isolated vascular tissuesExpand
Antihypertensive action of indapamide. Comparative studies in several experimental models.
1-(4-Chloro-3-sulfamylbenzamido)-2-methyl-indoline (indapamide), after single oral dose administration, showed antihypertensive activity in genetically hypertensive rats, DOCA/saline hypertensiveExpand
[Influence of indapamide on isolated rabbit arteries (author's transl)].
The effect of indapamide, a high ceiling diuretic, antihypertensive drug, was investigated in helically-cut strips of rabbit cerebral, coronary, renal, mesenteric and femoral arteries and aortae. TheExpand
Possible involvement of descending serotonergic systems in antinociception by centrally administered elcatonin in mice.
To elucidate the mechanisms of analgesic action of elcatonin, a synthetic analog of eel calcitonin, the effect of centrally injected elcatonin on acetic acid-induced writhing behavior was examined inExpand
Studies on agents with vasodilator and beta-blocking activities. IV.
A series of novel pyridazinone derivatives (II) having a phenoxypropanolamine moiety was synthesized. Their hypotensive and beta-blocking activities were evaluated after intravenous administration ofExpand
[Antihypertensive and diuretic effects of indapamide in normotensive and hypertensive rats (author's transl)].
Antihypertensive and diuretic actions of indapamide (SE-1520) were investigated in rats and compared with those of trichlormethiazide (TCMT). In normotensive rats, indapamide in a dose of 100 mg/kgExpand
Studies on Agents with Vasodilator and β-Blocking Activities. I
A series of novel pyridazinone derivatives (II) having a phenoxypropanolamine moiety was synthesized. Their hypotensive and β-blocking activities were evaluated after intravenous administration ofExpand
Studies on agents with vasodilator and beta-blocking activities. I.
A series of hydrazinopyridazine derivatives combined with a beta-blocking side chain were synthesized. When they were given intravenously to anesthetized rats, some of them exhibited both hypotensiveExpand
Studies on agents with vasodilator and beta-blocking activities. V. Synthesis and pharmacological activity of the optical isomers of TZC-5665.
Synthesis of the four optical isomers of TZC-5665 (1), a candidate for the treatment of congestive heart failure, was achieved by the reaction of chiral diaminopyridazinone (2) with chiral glycidylExpand
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