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Ultrasonically guided percutaneous microwave coagulation therapy for small hepatocellular carcinoma
The efficacy of percutaneous microwave coagulation therapy for single unresectable hepatocellular carcinoma measuring 2 cm or less in greatest dimension (small HCC) was assessed.
Reversible Smad-dependent signaling between tumor suppression and oncogenesis.
It is reported that Ras transformation suppresses TbetaRI-mediated pSmad3C signaling, which involves growth inhibition by down-regulating c-Myc, and stimulating JNK/pSmad2/3L pathway should suppress cancer progression by shifting Smad-dependent signaling from oncogenesis to tumor suppression.
Validation of a new prognostic staging system for hepatocellular carcinoma: The JIS score compared with the CLIP score
Multivariate analysis of the prognosis in all 4,525 patients proved the JIS score to be the best prognostic factor and the Akaike information criteria proved that the J IS scoring system was statistically a better model for predicting outcome than the CLIP scoring system.
Chronic inflammation associated with hepatitis C virus infection perturbs hepatic transforming growth factor β signaling, promoting cirrhosis and hepatocellular carcinoma
Results indicate that chronic inflammation associated with HCV infection shifts hepatocytic TGF‐β signaling from tumor‐suppression to fibrogenesis, accelerating liver fibrosis and increasing risk for HCC.
Smad2 and Smad3 phosphorylated at both linker and COOH-terminal regions transmit malignant TGF-beta signal in later stages of human colorectal cancer.
It is suggested that CDK4, together with JNK, alters tumor-suppressive TGF-beta signaling to malignant characteristics in later stages of human colorectal cancer.
Effect of vitamin K2 on the recurrence of hepatocellular carcinoma
The first interim analysis indicated that vitamin K2 did not prevent disease occurrence or death, with an HR of 1.150, and the study was discontinued in March 2007.
Percutaneous microwave coagulation therapy for patients with small hepatocellular carcinoma
The authors compared the efficacy of percutaneous microwave coagulation therapy (PMCT) and percutaneous ethanol injection therapy (PEIT) in the treatment of patients with cirrhosis and a solitary
p38 MAPK mediates fibrogenic signal through smad3 phosphorylation in rat myofibroblasts
Hepatic stellate cells (HSCs) spontaneously transdifferentiate into myofibroblast (MFB)‐phenotype on plastic dishes. This response recapitulates the features of activation in vivo. Transforming
TGF-β and HGF transmit the signals through JNK-dependent Smad2/3 phosphorylation at the linker regions
It is shown that either HGF or TGF-β treatment of normal stomach-origin cells activated the JNK pathway, thereafter inducing endogenous R-Smads phosphorylated at linker regions, which were the common phosphorylation sites for HGF and T GF-β signaling pathways.
Prediction of prognosis of primary biliary cirrhosis in Japan.
The clinical profile of primary biliary cirrhosis in Japan was clarified on the basis of data on 1066 patients attending 212 hospitals and institutions in this country and the patient's age and the serum bilirubin, albumin, and total cholesterol concentrations were significant predictors of the prognosis.