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Immunohistochemical localization of PDE10A in the rat brain
TLDR
Data suggest a role for PDE10A in regulating activity within both the striatonigral and striatopallidal pathways, and a second, distinct function for the enzyme in these regions. Expand
CP-154,526: a potent and selective nonpeptide antagonist of corticotropin releasing factor receptors.
TLDR
It is proposed that a CRF antagonist such as CP-154,526 could affirm the role of CRF in certain psychiatric diseases and may be of significant value in the treatment of these disorders. Expand
Ziprasidone (CP-88,059): a new antipsychotic with combined dopamine and serotonin receptor antagonist activity.
TLDR
The prediction of antipsychotic efficacy without severe motor side effects is supported by the relatively weak potency of ziprasidone to produce catalepsy in animals, contrasted with its potent antagonism of conditioned avoidance responding and dopamine agonist-induced locomotor activation and stereotypy. Expand
M2 Muscarinic Acetylcholine Receptor Knock-Out Mice Show Deficits in Behavioral Flexibility, Working Memory, and Hippocampal Plasticity
TLDR
Increased strength of GABAergic inhibition is a likely mechanism underlying the impaired synaptic plasticity observed with M2-/- hippocampi, and the persistent enhancement of excitatory synaptic transmission in CA1 pyramidal cells induced by the transient application of a low concentration of a muscarinic agonist was totally abolished in mice. Expand
The anti‐emetic effects of CP‐99,994 in the ferret and the dog: role of the NK1 receptor
TLDR
The hypothesis that the NK1 receptor antagonist properties of CP‐99,994 are responsible for its broad spectrum anti‐emetic effects is supported and it is suggested that CP‐ 99,994 acts within the brainstem, most probably within the nucleus tractus solitarius although the involvement of the area postrema could not be excluded. Expand
Activity and distribution of binding sites in brain of a nonpeptide substance P (NK1) receptor antagonist.
TLDR
CP-96,345, a nonpeptide substance P antagonist, is selective for the tachykinin NK1 receptor and inhibits substance P-induced excitation of locus ceruleus neurons in guinea pig brain. Expand
Alterations in gene regulation following inhibition of the striatum-enriched phosphodiesterase, PDE10A
TLDR
Findings support the hypothesis that PDE10A modulates signal transduction in both striatal output pathways and suggest that Pde10A inhibitors may offer a unique approach to the treatment of schizophrenia. Expand
Muscarinic activation of inwardly rectifying K+ conductance reduces EPSPs in rat hippocampal CA1 pyramidal cells
TLDR
The observed reduction of postsynaptic potentials is linked to the cholinergic activation of a GIRK conductance, which serves to partially shunt excitatory synaptic input. Expand
Metabolic mapping of the brain during rewarding self-stimulation.
TLDR
Rats trained in intracranial self-stimulation showed a pattern of changes in forebrain metabolic activity distinctly different from the pattern seen in rats stimulated by the experimenter. Expand
3-Benzisothiazolylpiperazine derivatives as potential atypical antipsychotic agents.
TLDR
In vivo 8e possesses activity consistent with an efficacious antipsychotic agent with less tendency to induce extrapyramidal side effects in man, and a combination of D2 receptor affinity and 5-HT2A/D2 ratio comparable to the atypical agent clozapine. Expand
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