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Immune cell profile of sentinel lymph nodes in patients with malignant melanoma – FOXP3+ cell density in cases with positive sentinel node status is associated with unfavorable clinical outcome

The results suggest that immune activation-associated markers in the primary tumor may have a higher impact than those in SLNs on the prognosis of the patients and are compatible with the hypothesis of functional competence of sentinel lymph nodes based on the prevalence of the studied immune cells.
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Tumor-infiltrating immune cells as potential biomarkers predicting response to treatment and survival in patients with metastatic melanoma receiving ipilimumab therapy

The results corroborate the previous findings suggesting an association between an immunologically active tumor microenvironment and response to ipilimumab treatment, and propose new potential biomarkers for predicting treatment efficacy and disease outcome.
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Correlation with lymphocyte infiltration, but lack of prognostic significance of MECA-79-positive high endothelial venules in primary malignant melanoma

It is shown that the number of MECA-79+ vessels correlates strongly with the peritumoral density of B and T lymphocytes, and higher HEV numbers were detected in tumors hosting tertiary lymphoid structures as well as in those of axial location compared with the ones in the extremity and in men compared with women.
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Ectopic lymphoid structures in primary cutaneous melanoma

It is shown that neogenesis of lymphoid structures does occur in primary melanomas, albeit with lower frequency compared to that reported in metastases, and B-cell aggregates did not show association with the outcome of the disease.
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Immunotherapy Bridge 2016 and Melanoma Bridge 2016: meeting abstracts

The findings identify a network of deregulated miRNAs as major players in the establishment of drug resistance in melanoma and link exercise with improved immunological control of tumor progression, suggesting that exercise could be a beneficial partner for immunotherapy.
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524 Tumor-infiltrating immune cells as potential biomarkers predicting response to treatment and survival in patients with metastatic melanoma receiving ipilimumab therapy

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Preliminary model-free results of a Hungarian robust artificial pancreas algorithm

Preliminary results show that the methodology has the potential to globally handle patient groups and efficiently support individualized control (ex. MPC) protocols.

Immunotherapy Bridge 2016 and Melanoma Bridge 2016: meeting abstracts

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Immune cell profile of sentinel lymph nodes in patients with malignant melanoma – FOXP3+ cell density in cases with positive sentinel node status is associated with unfavorable clinical outcome

Findings suggest that immune activation-associated markers in the primary tumor may have a higher impact than those in SLNs on the prognosis of the patients and are compatible with the hypothesis of functional competence of sentinel lymph nodes based on the prevalence of the studied immune cells.
View on Springer (opens in a new tab)

Abstract 453: Immune cell profile of sentinel lymph nodes in melanoma patients .

Findings suggest that immune cells residing in the primary tumor, rather than those in sentinel lymph nodes, may be crucial in the development of antitumor immune response reflected in influencing the outcome of the disease.
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