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Late angiotensin II receptor blockade in progressive rat mesangioproliferative glomerulonephritis: new insights into mechanisms
Mesangioproliferative glomerulonephritis is the most common nephritis worldwide. We examined the effects of low‐ and high‐dose telmisartan, an angiotensin II receptor blocker, in rats with… Expand
[Improvement of an electromagnetic articulograph for registering tongue and lip movements].
CCN3 is a novel endogenous PDGF-regulated inhibitor of glomerular cell proliferation.
CCN proteins affect cell proliferation, migration, attachment, and differentiation. We identified CCN3 as a suppressed gene following platelet-derived growth factor (PDGF)-BB or -DD stimulation in a… Expand
A new synthesis of chiral acetic acid
Pyrolysis of the doubly-labelled chiral ether (7) leads to the formation of a product containing a chiral methyl group of predictable configuration, thus providing a new method for the generation of… Expand
Antiviral activity and pharmacokinetics of HOE 602, an acyclic nucleoside, in animal models.
- I. Winkler, E. Winkelmann, T. Scholl, M. Rösner, G. Jähne, M. Helsberg
- Biology, Medicine
- Antiviral research
- 1 August 1990
The acyclic nucleoside derivative HOE 602 (2-amino-9-[1,3-bis(isopropoxy)-2-propoxymethyl]purine) was evaluated for its antiviral activity in cell culture and for its therapeutic efficacy in mice… Expand
Regioselective Synthesis and Antiviral Activity of Purine Nucleoside Analogues with Acyclic Substituents at N7
Stereochemical Studies on Pre-Anthraquinones and Dimeric Anthraquinone Pigments
Labelling studies have shown that the biosynthesis of emodin (6) and related anthraquinone pigments in fungi and higher plants occurs via the acetate/malonate pathway (ref. 1). Details of the early… Expand
The inhibitory effect of HOE 731 in isolated rabbit gastric glands.
- A. Herling, M. Becht, +4 authors R. Rippel
- Chemistry, Medicine
- Biochemical pharmacology
- 15 October 1990
HOE 731, a substituted thienoimidazole derivative, was studied on [14C] aminopyrine uptake and oxygen consumption in isolated rabbit gastric glands. HOE 731 caused a concentration-dependent… Expand
2-[(2-pyridylmethyl)sulfinyl]-1H-thieno[3,4-d]imidazoles. A novel class of gastric H+/K(+)-ATPase inhibitors.
- K. Weidmann, A. Herling, +6 authors H. Metzger
- Chemistry, Medicine
- Journal of medicinal chemistry
- 7 February 1992
2-[(2-Pyridylmethyl)sulfinyl]thienoimidazoles were synthesized and investigated as potential inhibitors of gastric H+/K(+)-ATPase. The [3,4-d] isomers of the two possible thienoimidazole series were… Expand
Gastric acid inhibitory profile of saviprazole (HOE 731) compared to omeprazole.
Saviprazole (HOE 731), a substituted thienoimidazole, caused a dose-dependent inhibition of gastric acid secretion in dogs and rats with ID50 values which were not significantly different from that… Expand