Transcriptional interference between c-Jun and the glucocorticoid receptor: Mutual inhibition of DNA binding due to direct protein-protein interaction
- H. Yang-Yen, J. Chambard, M. Karin
- BiologyCell
- 21 September 1990
Antitrypanosomal and Antileishmanial Activities of Flavonoids and Their Analogues: In Vitro, In Vivo, Structure-Activity Relationship, and Quantitative Structure-Activity Relationship Studies
- D. Taşdemir, M. Kaiser, P. Rüedi
- Chemistry, BiologyAntimicrobial Agents and Chemotherapy
- 1 April 2006
A large set of flavonoid aglycones and glycosides were surveyed, as well as a panel of other related compounds of phenolic and phenylpropanoid nature, for their in vitro activities against Trypanosoma brucei rhodesiense, T. cruzi, and Leishmania donovani, and generally, the test compounds lacked cytotoxicity in vitro and in vivo.
11&bgr;-Hydroxysteroid Dehydrogenase Type 2 Activity in Hypothalamic Paraventricular Nucleus Modulates Sympathetic Excitation
- Zhi-hua Zhang, Yu-Ming Kang, R. Felder
- BiologyHYPERTENSION
- 1 July 2006
The present studies suggest that MR in PVN contribute to sympathetic regulation and may be activated by aldosterone or corticosterone (or cortisol in humans) depending on the state of 11&bgr;-HSD-2 activity.
Inhibition of transcription factor NF-kappaB by sesquiterpene lactones: a proposed molecular mechanism of action.
- P. Rüngeler, V. Castro, T. Schmidt
- Chemistry, BiologyBioorganic & Medicinal Chemistry
- 1 November 1999
The alpha-subunit of the epithelial sodium channel is an aldosterone-induced transcript in mammalian collecting ducts, and this transcriptional response is mediated via distinct cis-elements in the…
- V. E. Mick, O. Itani, R. Loftus, R. Husted, T. Schmidt, C. Thomas
- Biology, MedicineMolecular endocrinology
- 1 April 2001
Assessment of deletion constructs confirmed that a single imperfect glucocorticoid response element (GRE) is necessary and sufficient to confer the aldosterone responsiveness to the alpha ENaC gene promoter in MDCK-C7 and HT-29 cells.
Reactivity of dimethyl fumarate and methylhydrogen fumarate towards glutathione and N-acetyl-L-cysteine--preparation of S-substituted thiosuccinic acid esters.
- T. Schmidt, Muharrem Ak, U. Mrowietz
- Biology, ChemistryBioorganic & Medicinal Chemistry
- 2007
Pharmacological properties of the extract and some isolated compounds of Clausena lansium stem bark: anti-trichomonal, antidiabetic, anti-inflammatory, hepatoprotective and antioxidant effects.
- A. C. Adebajo, E. Iwalewa, E. Verspohl
- Biology, MedicineJournal of Ethnopharmacology
- 25 February 2009
Homodimer formation is rate-limiting for high affinity DNA binding by glucocorticoid receptor.
A GRE mutant which contained only a half-binding site and which was unable to bind GR homodimers was also unable to confer glucocorticoid-inducible transcription, suggesting that homodimer formation is rate-limiting for high affinity GRE binding.
The potential of secondary metabolites from plants as drugs or leads against protozoan neglected diseases - part II.
- T. Schmidt, S. A. Khalid, A. Tempone
- BiologyCurrent Medicinal Chemistry
- 2012
It is illustrated that plant secondary metabolites represent an immensely rich source of chemical diversity with an extremely high potential to yield a wealth of lead structures towards new therapies for NTDs.
Tirucallic Acids Are Novel Pleckstrin Homology Domain-Dependent Akt Inhibitors Inducing Apoptosis in Prostate Cancer Cells
- A. Estrada, T. Syrovets, T. Simmet
- Chemistry, BiologyMolecular Pharmacology
- 1 March 2010
The tirucallic acid derivatives represent a new class of Akt inhibitors with antitumor properties that inhibited proliferation and induced apoptosis in tumors xenografted onto chick chorioallantoic membranes and decreased the growth of pre-established prostate tumors in nude mice without overt systemic toxicity.
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