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Molecular characterization of volume-sensitive SK(Ca) channels in human liver cell lines.
In human liver, Ca(2+)-dependent changes in membrane K(+) permeability play a central role in coordinating functional interactions between membrane transport, metabolism, and cell volume. On theExpand
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Ursodeoxycholate increases cytosolic calcium concentration and activates Cl- currents in a biliary cell line.
BACKGROUND & AIMS Ursodeoxycholate (UDC) stimulates a bicarbonate-rich choleresis, but the cellular mechanisms involved are not fully established. Because ductular secretion also increases biliaryExpand
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Regulation of biliary secretion through apical purinergic receptors in cultured rat cholangiocytes.
To evaluate whether ATP in bile serves as a signaling factor regulating ductular secretion, voltage-clamp studies were performed using a novel normal rat cholangiocyte (NRC) model. In the presence ofExpand
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Cytosolic Ca2+ and protein kinase Calpha couple cellular metabolism to membrane K+ permeability in a human biliary cell line.
Cholangiocytes represent an important target of injury during the ischemia and metabolic stress that accompanies liver preservation. Since K+ efflux serves to minimize injury during ATP depletion inExpand
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Ca(2+)-activated C1- channels in a human biliary cell line: regulation by Ca2+/calmodulin-dependent protein kinase.
Biliary epithelial cells contribute to bile formation through absorption and secretion of fluid and electrolytes. Recent studies indicate that membrane Cl- permeability is regulated in part byExpand
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Plasma kinetics and biliary excretion of colchicine in patients with chronic liver disease after oral administration of a single dose and after long-term treatment.
Plasma kinetics and biliary excretion of colchicine in patients with chronic liver disease were evaluated after oral administration of a single dose and after long-term treatment. A single oral doseExpand
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Antibiotic prophylaxis after variceal hemorrhage reduces incidence of early rebleeding.
BACKGROUND/AIMS This study aims to evaluate the role of new onset infection in the initiation of early rebleeding after variceal hemorrhage in patients with liver cirrhosis and the effect ofExpand
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Guanylin regulates chloride secretion in the human gallbladder via the bile fluid.
BACKGROUND & AIMS The biliary epithelium of bile ducts and gallbladder modifies the composition of primary hepatic bile by absorption and secretion of an electrolyte-rich fluid. The underlyingExpand
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Functional interactions between oxidative stress, membrane Na(+) permeability, and cell volume in rat hepatoma cells.
BACKGROUND & AIMS Oxidative stress leads to a rapid initial loss of liver cell volume, but the adaptive mechanisms that serve to restore volume have not been defined. This study aimed to evaluate theExpand
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Stimulation of cyclic guanosine monophosphate production by natriuretic peptide in human biliary cells.
BACKGROUND & AIMS Guanosine 3',5'-cyclic monophosphate (cGMP), whose production is stimulated by the interaction of nitric oxide, natriuretic peptides, and guanylin with their respective guanylateExpand
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