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CNS plasticity and assessment of forelimb sensorimotor outcome in unilateral rat models of stroke, cortical ablation, parkinsonism and spinal cord injury
A battery of useful tests for evaluating sensorimotor function and plasticity acutely and chronically in unilateral rat models of central nervous system injury are reviewed and OP-1 showed a beneficial effect on limb use asymmetry in the cylinder test. Expand
Long-lasting neural and behavioral effects of iron deficiency in infancy.
Evidence of long-term effects of iron deficiency in infancy and follow-up studies from preschool age to adolescence report poorer cognitive, motor, and social-emotional function, as well as persisting neurophysiologic differences. Expand
Forced Limb-Use Effects on the Behavioral and Neurochemical Effects of 6-Hydroxydopamine
Results suggest that physical therapy may be beneficial in Parkinson's disease and show remarkable sparing of striatal DA, its metabolites, and the expression of the vesicular monoamine transporter, suggesting a decrease in the extent of DA neuron degeneration. Expand
Repeated intravenous amphetamine exposure: Rapid and persistent sensitization of 50-kHz ultrasonic trill calls in rats
It is possible that 50-kHz USV recordings could provide a potentially valuable behavioral measure of sensitization linked to enhanced incentive salience and increased tendency to self-administer drugs of abuse. Expand
Overgrowth and pruning of dendrites in adult rats recovering from neocortical damage
Unilateral lesions to the forelimb representation (FL) area of the rat sensorimotor cortex caused a time-dependent increase in the dendritic arborization of layer V pyramidal neurons in theExpand
Use-dependent growth of pyramidal neurons after neocortical damage
Neither a lesion nor asymmetrical limb use alone could account for the dendritic overgrowth--it depended on aLesion-behavior interaction, and greater sensorimotor impairments were found when thedendritic growth was blocked, suggesting that the neural growth and/or associated limb-use behavior were related to functional recovery from the cortical damage. Expand
Animal models of neurological deficits: how relevant is the rat?
Rat models of hemiplegia, neglect and tactile extinction are useful in assessing the outcome of ischaemic or traumatic brain injury, and in monitoring the effects of therapeutic interventions. Expand
Transplants of Fibroblasts Genetically Modified to Express BDNF Promote Regeneration of Adult Rat Rubrospinal Axons and Recovery of Forelimb Function
Transplants of fibroblasts genetically engineered to produce brain-derived neurotrophic factor (BDNF) would promote rubrospinal tract (RST) regeneration in adult rats showed significant recovery of forelimb usage, which was abolished by a second lesion that transected the regenerated axons. Expand
Statins increase neurogenesis in the dentate gyrus, reduce delayed neuronal death in the hippocampal CA3 region, and improve spatial learning in rat after traumatic brain injury.
Treatment of TBI with statins improves spatial learning and neurogenesis in rats subjected to controlled cortical impact and provides a therapeutic effect superior to treatment with atorvastatin, suggesting that statins may be candidates for treatment ofTBI. Expand
Behavioral Tests After Intracerebral Hemorrhage in the Rat
A battery of sensorimotor function tests were used to examine the neurological effects of ICH in the rat and to examine which components of the hematoma are involved in generating those effects. Expand