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Claudin-2 expression induces cation-selective channels in tight junctions of epithelial cells
Tight junctions seal the paracellular pathway of epithelia but, in leaky tissues, also exhibit specific permeability. In order to characterize the contribution of claudin-2 to barrier and…
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Molecular and functional basis of phenotypic convergence in white lizards at White Sands
TLDR
The results demonstrate that even when the same gene is responsible for phenotypic convergence, differences in molecular mechanism can have dramatic consequences on trait expression and ultimately the adaptive trajectory.
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Functional and structural complexity of signal transduction via G-protein-coupled receptors.
TLDR
Elaborate studies have significantly enhanced knowledge of the functional anatomy of G-protein-coupled receptors, and the concept has emerged that receptor function can be modulated with high specificity by coexpressed receptor fragments and may have significant clinical impact in the future.
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Nuclear envelope proteomics: Novel integral membrane proteins of the inner nuclear membrane
TLDR
A comprehensive characterization of the nuclear envelope (NE) proteome is presented and it is shown that two novel transmembrane proteins reside in the inner nuclear membrane and likely interact with the nuclear lamina.
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Human formyl peptide receptor 2 senses highly pathogenic Staphylococcus aureus.
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Gpr126 Functions in Schwann Cells to Control Differentiation and Myelination via G-Protein Activation
TLDR
A model in which Gpr126 functions in SCs for proper development and myelination is supported and evidence that these functions are mediated via G-protein-signaling pathways is provided.
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Site-directed Mutagenesis Identifies Residues Involved in Ligand Recognition in the Human A2a Adenosine Receptor (*)
TLDR
A molecular model based on the structure of rhodopsin, in which the 5′-NH in NECA is hydrogen bonded to Ser-277 and His-278, was developed in order to visualize the environment of the ligand binding site.
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Mutant G-protein-coupled receptors as a cause of human diseases.
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International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G Protein–Coupled Receptors
TLDR
This review covers all major biologic aspects of Adhesion GPCRs, including evolutionary origins, interaction partners, signaling, expression, physiologic functions, and therapeutic potential.
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A Melanocortin 1 Receptor Allele Suggests Varying Pigmentation Among Neanderthals
The melanocortin 1 receptor (MC1R) regulates pigmentation in humans and other vertebrates. Variants of MC1R with reduced function are associated with pale skin color and red hair in humans of…
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