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A new antibiotic kills pathogens without detectable resistance
The properties of this compound suggest a path towards developing antibiotics that are likely to avoid development of resistance, as well as several methods to grow uncultured organisms by cultivation in situ or by using specific growth factors.
Identification of sequestered chloroplasts in photosynthetic and non-photosynthetic sacoglossan sea slugs (Mollusca, Gastropoda)
- G. Christa, K. Händeler, T. Schäberle, G. König, H. Wägele
- BiologyFrontiers in Zoology
- 21 February 2014
It is found that certain chloroplasts are most likely essential for establishing functional kleptoplasty and narrowed down the algal species that seem to be essential for long-term-functional photosynthesis: Halimeda, Caulerpa, Penicillus, Avrainvillea, Acetabularia and Vaucheria.
A new antibiotic selectively kills Gram-negative pathogens
Bacterial symbionts of animals may contain antibiotics that are particularly suitable for development into therapeutics; one such compound, darobactin, is active against important Gram-negative pathogens both in vitro and in animal models of infection.
Salimyxins and Enhygrolides: Antibiotic, Sponge‐Related Metabolites from the Obligate Marine Myxobacterium Enhygromyxa salina
- Stephan Felder, S. Kehraus, Edith Neu, G. Bierbaum, T. Schäberle, G. König
- Biology, ChemistryChembiochem : a European journal of chemical…
- 22 July 2013
These are the first natural products obtained from Enhygromyxa species, and the salimyxins and enhygrolides, representing structurally most unusual degraded sterols, are close to identical to demethylincisterol from the sponge Homaxinella sp.
The genome analysis of Candidatus Burkholderia crenata reveals that secondary metabolism may be a key function of the Ardisia crenata leaf nodule symbiosis.
Evidence is provided that the bacterial symbionts are responsible for the synthesis of compound FR900359, a cyclic depsipeptide with biomedical properties previously isolated from leaves of A. crenata.
What remains after 2 months of starvation? Analysis of sequestered algae in a photosynthetic slug, Plakobranchus ocellatus (Sacoglossa, Opisthobranchia), by barcoding
- G. Christa, Lily Wescott, T. Schäberle, G. König, H. Wägele
- Environmental Science, BiologyPlanta
- 1 February 2013
It is shown here that at least two (or possibly three) barcode markers are required to cover the entire food spectrum in future analyses of Sacoglossa, and it is suggested that P. ocellatus is a species complex and feeds on a broad variety of Ulvophyceae.
Investigation of the functional properties and regulation of three glutamine synthetase-like genes in Streptomyces coelicolor A3(2)
Findings support the conclusion that glnA2, GlnA3, andglnA4 are not directly involved in l-glutamine synthesis and nitrogen assimilation and are not subject to nitrogen control in S. coelicolor.
Antibiotics from myxobacteria.
- T. Schäberle, Friederike Lohr, Alexander Schmitz, G. König
- BiologyNatural product reports
- 11 June 2014
The review provides an overview of the potential of specific compounds, suitable for future investigations and possible clinical applications, and points out their particularities and, if known, their mode of action.
A New Sesquiterpenoid Aminoquinone from an Indonesian Marine Sponge
The isolated merosesquiterpenoids showed antibacterial activity and prompt future structure activity relationship (SAR) studies concerning the various bioactivities observed for this group of natural products.
Salimabromide: unexpected chemistry from the obligate marine myxobacterium Enhygromxya salina.
Salimabromide has a new tetracyclic carbon skeleton, comprising a brominated benzene ring, a furano lactone residue, and a cyclohexane ring, bridged by a seven-membered cyclic moiety.