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STAT-1 Interacts with p53 to Enhance DNA Damage-induced Apoptosis*
TLDR
It is shown that STAT-1 is required for optimal DNA damage-induced apoptosis, and is another member of a growing family of protein partners able to modulate the p53-activated apoptotic pathway. Expand
Ischemia-induced STAT-1 Expression and Activation Play a Critical Role in Cardiomyocyte Apoptosis*
TLDR
It is shown that exposure of cardiac cells to simulated ischemia results in apoptosis and is accompanied by phosphorylation and increased expression and transcriptional activity of STAT-1, acting at least in part via a caspase-1 activation-dependent pathway. Expand
Apoptosis of Endothelial Cells Precedes Myocyte Cell Apoptosis in Ischemia/Reperfusion Injury
TLDR
The radial spread of apoptosis to surrounding cardiac myocytes suggests that reperfusion induces the release of soluble pro-apoptotic mediators from endothelial cells that promote myocyte apoptosis. Expand
Urocortin inhibits Beclin1-mediated autophagic cell death in cardiac myocytes exposed to ischaemia/reperfusion injury.
TLDR
It is demonstrated that autophagy is also induced by a single cycle of ischaemia/reperfusion (I/R in neonatal and adult rat cardiac myocytes) and reduction of Beclin1 expression in cardiac myocyte by RNAi reduces I/R-induced autophileagy and this is associated with enhanced cell survival. Expand
Impact of highly active antiretroviral therapy in HIV-positive patients with cardiac involvement.
TLDR
HAART has significantly decreased the incidence of cardiac involvement, especially pericarditis, arrhythmias, and dilated cardiomyopathy in HIV-infected patients, especially in those in the late stage of the disease. Expand
Epigallocatechin‐3‐gallate inhibits STAT‐1 activation and protects cardiac myocytes from ischemia/reperfusion‐ induced apoptosis
TLDR
It is shown that consumption of green tea is able to mediate cardioprotection and enhance cardiac function during I/R injury and it is postulated that a similar action can be implemented in the clinical setting to minimize STAT‐1 activation levels in patients with acute coronary artery disease (CAD). Expand
Peripartum cardiomyopathy: a comprehensive review.
TLDR
The prognosis is poor in patients with persistent cardiomyopathy and portends worse survival, and early diagnosis and initiation of treatment are essential to optimize pregnancy outcome. Expand
Minocycline inhibits caspase activation and reactivation, increases the ratio of XIAP to smac/DIABLO, and reduces the mitochondrial leakage of cytochrome C and smac/DIABLO.
TLDR
Because of its safety record and multiple novel mechanisms of action, minocycline may be a valuable cardioprotective agent to ameliorate cardiac dysfunction and cell loss associated with cardiac I/R injury. Expand
Different Signaling Pathways Induce Apoptosis in Endothelial Cells and Cardiac Myocytes During Ischemia/Reperfusion Injury
TLDR
In the present study, performed in the isolated rat heart exposed either to ischemia alone or ischemIA followed by reperfusion, cleavage of caspase-9 was observed primarily in endothelial cells, whereas casp enzyme-8 cleavage was only found in cardiomyocytes, where it progressively increased throughout reperfusions. Expand
Cardiovascular Complications of Cancer Therapy: Best Practices in Diagnosis, Prevention, and Management: Part 1.
TLDR
With the number of cancer survivors expanding quickly, the time has come for cardiologists to work closely with cancer specialists to prevent and treat cancer therapy-induced cardiovascular complications. Expand
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