• Publications
  • Influence
Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production
Systems for protein degradation are essential for tight control of the inflammatory immune response. Autophagy, a bulk degradation system that delivers cytoplasmic constituents into autolysosomes,Expand
  • 1,580
  • 104
  • PDF
Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages
Beclin 1, a protein essential for autophagy, binds to hVps34/Class III phosphatidylinositol-3-kinase and UVRAG. Here, we have identified two Beclin 1 associated proteins, Atg14L and Rubicon. Atg14LExpand
  • 905
  • 68
  • PDF
The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection
Polarization of macrophages to M1 or M2 cells is important for mounting responses against bacterial and helminth infections, respectively. Jumonji domain containing-3 (Jmjd3), a histone 3 Lys27Expand
  • 834
  • 47
  • PDF
Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response
Microbial nucleic acids are critical for the induction of innate immune responses, a host defense mechanism against infection by microbes. Recent studies have indicated that double-stranded DNAExpand
  • 491
  • 43
  • PDF
KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference
Significance Alcohol is a widely consumed drug in western societies that can lead to addiction. A small shift in consumption can have dramatic consequences on public health. We performed the largestExpand
  • 145
  • 11
  • PDF
Antiviral protein Viperin promotes Toll-like receptor 7- and Toll-like receptor 9-mediated type I interferon production in plasmacytoid dendritic cells.
Toll-like receptor 7 (TLR7) and TLR9 sense viral nucleic acids and induce production of type I interferon (IFN) by plasmacytoid dendritic cells (pDCs) to protect the host from virus infection. WeExpand
  • 151
  • 11
Electrophilic properties of itaconate and derivatives regulate the IκBζ–ATF3 inflammatory axis
Metabolic regulation has been recognized as a powerful principle guiding immune responses. Inflammatory macrophages undergo extensive metabolic rewiring1 marked by the production of substantialExpand
  • 152
  • 7
Identification of an atypical monocyte and committed progenitor involved in fibrosis
Monocytes and macrophages comprise a variety of subsets with diverse functions. It is thought that these cells play a crucial role in homeostasis of peripheral organs, key immunological processes andExpand
  • 129
  • 5
Zinc-finger antiviral protein mediates retinoic acid inducible gene I–like receptor-independent antiviral response to murine leukemia virus
When host cells are infected by an RNA virus, pattern-recognition receptors (PRRs) recognize the viral RNA and induce the antiviral innate immunity. Toll-like receptor 7 (TLR7) detects the genomicExpand
  • 50
  • 4
  • PDF
Pivotal role of RNA-binding E3 ubiquitin ligase MEX3C in RIG-I–mediated antiviral innate immunity
Significance Upon virus infection, host cells detect viral nucleic acids and induce antiviral innate immune responses by producing cytokines. The retinoic acid inducible gene-1 (RIG-I)-like receptorsExpand
  • 40
  • 3