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- Publications
- Influence
Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production
- T. Saitoh, Naonobu Fujita, +13 authors S. Akira
- Biology, Medicine
- Nature
- 13 November 2008
Systems for protein degradation are essential for tight control of the inflammatory immune response. Autophagy, a bulk degradation system that delivers cytoplasmic constituents into autolysosomes,… Expand
Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages
- K. Matsunaga, T. Saitoh, +10 authors T. Yoshimori
- Biology, Medicine
- Nature Cell Biology
- 8 March 2009
Beclin 1, a protein essential for autophagy, binds to hVps34/Class III phosphatidylinositol-3-kinase and UVRAG. Here, we have identified two Beclin 1 associated proteins, Atg14L and Rubicon. Atg14L… Expand
The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection
- T. Satoh, O. Takeuchi, +15 authors S. Akira
- Biology, Medicine
- Nature Immunology
- 1 October 2010
Polarization of macrophages to M1 or M2 cells is important for mounting responses against bacterial and helminth infections, respectively. Jumonji domain containing-3 (Jmjd3), a histone 3 Lys27… Expand
Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response
- T. Saitoh, Naonobu Fujita, +13 authors S. Akira
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 8 December 2009
Microbial nucleic acids are critical for the induction of innate immune responses, a host defense mechanism against infection by microbes. Recent studies have indicated that double-stranded DNA… Expand
KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference
- G. Schumann, C. Liu, +124 authors P. Elliott
- Medicine
- Proceedings of the National Academy of Sciences
- 28 November 2016
Significance Alcohol is a widely consumed drug in western societies that can lead to addiction. A small shift in consumption can have dramatic consequences on public health. We performed the largest… Expand
Antiviral protein Viperin promotes Toll-like receptor 7- and Toll-like receptor 9-mediated type I interferon production in plasmacytoid dendritic cells.
Toll-like receptor 7 (TLR7) and TLR9 sense viral nucleic acids and induce production of type I interferon (IFN) by plasmacytoid dendritic cells (pDCs) to protect the host from virus infection. We… Expand
Electrophilic properties of itaconate and derivatives regulate the IκBζ–ATF3 inflammatory axis
- Monika Bambousková, L. Gorvel, +28 authors Maxim N. Artyomov
- Chemistry, Medicine
- Nature
- 1 April 2018
Metabolic regulation has been recognized as a powerful principle guiding immune responses. Inflammatory macrophages undergo extensive metabolic rewiring1 marked by the production of substantial… Expand
Identification of an atypical monocyte and committed progenitor involved in fibrosis
- T. Satoh, K. Nakagawa, +9 authors S. Akira
- Biology, Medicine
- Nature
- 5 January 2017
Monocytes and macrophages comprise a variety of subsets with diverse functions. It is thought that these cells play a crucial role in homeostasis of peripheral organs, key immunological processes and… Expand
Zinc-finger antiviral protein mediates retinoic acid inducible gene I–like receptor-independent antiviral response to murine leukemia virus
- Hanna Lee, J. Komano, +10 authors S. Akira
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 8 July 2013
When host cells are infected by an RNA virus, pattern-recognition receptors (PRRs) recognize the viral RNA and induce the antiviral innate immunity. Toll-like receptor 7 (TLR7) detects the genomic… Expand
Pivotal role of RNA-binding E3 ubiquitin ligase MEX3C in RIG-I–mediated antiviral innate immunity
- Kanako Kuniyoshi, O. Takeuchi, +4 authors T. Kawai
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 27 March 2014
Significance Upon virus infection, host cells detect viral nucleic acids and induce antiviral innate immune responses by producing cytokines. The retinoic acid inducible gene-1 (RIG-I)-like receptors… Expand