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New Component of the Vacuolar Class C-Vps Complex Couples Nucleotide Exchange on the Ypt7 Gtpase to Snare-Dependent Docking and Fusion
The class C subset of vacuolar protein sorting (Vps) proteins (Vps11, Vps18, Vps16 and Vps33) assembles into a vacuole/prevacuole-associated complex. Here we demonstrate that the class C-Vps complexExpand
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A Functional Genomics Strategy Reveals Rora as a Component of the Mammalian Circadian Clock
The mammalian circadian clock plays an integral role in timing rhythmic physiology and behavior, such as locomotor activity, with anticipated daily environmental changes. The master oscillatorExpand
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ESRP1 and ESRP2 are epithelial cell-type-specific regulators of FGFR2 splicing.
Cell-type-specific expression of epithelial and mesenchymal isoforms of Fibroblast Growth Factor Receptor 2 (FGFR2) is achieved through tight regulation of mutually exclusive exons IIIb and IIIc,Expand
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Melanopsin (Opn4) Requirement for Normal Light-Induced Circadian Phase Shifting
The master circadian oscillator in the hypothalamic suprachiasmatic nucleus is entrained to the day/night cycle by retinal photoreceptors. Melanopsin (Opn4), an opsin-based photopigment, is a primaryExpand
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Endosomal transport function in yeast requires a novel AAA‐type ATPase, Vps4p
In a late‐Golgi compartment of the yeast Saccharomyces cerevisiae, vacuolar proteins such as carboxypeptidase Y (CPY) are actively sorted away from the secretory pathway and transported to theExpand
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Class C Vps protein complex regulates vacuolar SNARE pairing and is required for vesicle docking/fusion.
In yeast, the Class C Vps protein complex (C-Vps complex), composed of Vps11, Vps16, Vps18, and Vps33, functions in Golgi-to-vacuole protein transport. In this study, we characterized and purifiedExpand
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Phox domain interaction with PtdIns(3)P targets the Vam7 t-SNARE to vacuole membranes
Specific recognition of phosphoinositides is crucial for protein sorting and membrane trafficking. Protein transport to the yeast vacuole depends on the Vam7 t-SNARE and its phox homology (PX)Expand
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FAP-1: a protein tyrosine phosphatase that associates with Fas.
Fas is a cell surface receptor that controls a poorly understood signal transduction pathway that leads to cell death by means of apoptosis. A protein tyrosine phosphatase, FAP-1, capable ofExpand
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Melanopsin Is Required for Non-Image-Forming Photic Responses in Blind Mice
Although mice lacking rod and cone photoreceptors are blind, they retain many eye-mediated responses to light, possibly through photosensitive retinal ganglion cells. These cells express melanopsin,Expand
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Feedback repression is required for mammalian circadian clock function
Direct evidence for the requirement of transcriptional feedback repression in circadian clock function has been elusive. Here, we developed a molecular genetic screen in mammalian cells to identifyExpand
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