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Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN
PTEN is a tumor suppressor with sequence homology to protein tyrosine phosphatases and the cytoskeletal protein tensin. mPTEN-mutant mouse embryos display regions of increased proliferation. InExpand
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Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death
Programmed cell death is a fundamental requirement for embryogenesis, organ metamorphosis and tissue homeostasis. In mammals, release of mitochondrial cytochrome c leads to the cytosolic assembly ofExpand
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Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b
The signalling thresholds of antigen receptors and co-stimulatory receptors determine immunity or tolerance to self molecules. Changes in co-stimulatory pathways can lead to enhanced activation ofExpand
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Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas.
PTEN is a tumor suppressor gene mutated in many human cancers, and its expression is reduced or absent in almost half of hepatoma patients. We used the Cre-loxP system to generate aExpand
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Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration.
Phosphoinositide 3-kinases (PI3Ks) regulate fundamental cellular responses such as proliferation, apoptosis, cell motility, and adhesion. Viable gene-targeted mice lacking the p110 catalytic subunitExpand
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High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice
BACKGROUND Germ-line and sporadic mutations in the tumor suppressor gene PTEN (also known as MMAC or TEP1), which encodes a dual-specificity phosphatase, cause a variety of cancers such as CowdenExpand
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The Osteoclast Differentiation Factor Osteoprotegerin-Ligand Is Essential for Mammary Gland Development
Osteoprotegerin-ligand (OPGL) is a key osteoclast differentiation/activation factor essential for bone remodeling. We report that mice lacking OPGL or its receptor RANK fail to form lobulo-alveolarExpand
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Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-γ and PTEN
Wound healing is essential for maintaining the integrity of multicellular organisms. In every species studied, disruption of an epithelial layer instantaneously generates endogenous electric fields,Expand
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Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-gamma and PTEN.
Wound healing is essential for maintaining the integrity of multicellular organisms. In every species studied, disruption of an epithelial layer instantaneously generates endogenous electric fields,Expand
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Critical Roles of Pten in B Cell Homeostasis and Immunoglobulin Class Switch Recombination
Pten is a tumor suppressor gene mutated in human cancers. We used the Cre-loxP system to generate a B cell–specific mutation of Pten in mice (bPten flox/floxmice). bPten flox/flox mice showedExpand
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