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Mutations in NALP12 cause hereditary periodic fever syndromes
NALP proteins, also known as NLRPs, belong to the CATERPILLER protein family involved, like Toll-like receptors, in the recognition of microbial molecules and the subsequent activation ofExpand
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Measuring European population stratification with microarray genotype data.
A proper understanding of population genetic stratification--differences in individual ancestry within a population--is crucial in attempts to find genes for complex traits through associationExpand
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MEFV-Gene analysis in armenian patients with Familial Mediterranean fever: diagnostic value and unfavorable renal prognosis of the M694V homozygous genotype-genetic and therapeutic implications.
Familial Mediterranean fever (FMF) is a recessively inherited disorder that is common in patients of Armenian ancestry. To date, its diagnosis, which can be made only retrospectively, is one ofExpand
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Mitochondrial DNA and Y‐Chromosome Variation in the Caucasus
We have analyzed mtDNA HVI sequences and Y chromosome haplogroups based on 11 binary markers in 371 individuals, from 11 populations in the Caucasus and the neighbouring countries of Turkey and Iran.Expand
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Country as the primary risk factor for renal amyloidosis in familial Mediterranean fever.
OBJECTIVE Familial Mediterranean fever (FMF), the prototype of autoinflammatory disorders, is caused by recessive mutations in the MEFV gene. Some FMF patients develop renal amyloidosis, aExpand
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Identification of MEFV-independent modifying genetic factors for familial Mediterranean fever.
Familial Mediterranean fever (FMF) is a recessively inherited disorder predisposing to renal amyloidosis and associated with mutations in MEFV, a gene encoding a protein of unknown function.Expand
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Guidelines for the genetic diagnosis of hereditary recurrent fevers
Hereditary recurrent fevers (HRFs) are a group of monogenic autoinflammatory diseases characterised by recurrent bouts of fever and serosal inflammation that are caused by pathogenic variants inExpand
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Identification and functional consequences of a recurrent NLRP12 missense mutation in periodic fever syndromes.
OBJECTIVE To gain insight into the molecular bases of genetically unexplained periodic fever syndromes (PFS) by screening NLRP12, a gene in which only a nonsense and a splice site mutation have soExpand
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Testing hypotheses of language replacement in the Caucasus: evidence from the Y-chromosome
A previous analysis of mtDNA variation in the Caucasus found that Indo-European-speaking Armenians and Turkic-speaking Azerbaijanians were more closely related genetically to other CaucasusExpand
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Transferable clastogenic activity in plasma from persons exposed as salvage personnel of the Chernobyl reactor
Clastogenic factors were first described in the plasma of people who had been accidentally or therapeutically irradiated. They were found also in A-bomb survivors, where they persisted for many yearsExpand
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