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New Morphinane and Hasubanane Alkaloids from Stephania cepharantha
Six morphinane alkaloids, cephasamine (3), cephakicine (4), tannagine (6), 14-episinomenine (7), FK-3000 (8), and sinoacutine (9), and five hasubanane alkaloids, cephatonine (5), cepharamine (10),… Expand
Biochemical and pathological study of endogenous 1-benzyl-1,2,3,4-tetrahydroisoquinoline-induced parkinsonism in the mouse
It is concluded that the 1-BnTIQ-induced bradykinesia has a different mechanism of action than that underlying the MPTP-induced depletion of striatal DA neurons. Expand
Alkaloidal Constituents of the Leaves of Stephania cepharantha Cultivated in Japan: Structure of Cephasugine, a New Morphinane Alkaloid.
TOTAL SYNTHESIS OF THE AMARYLLIDACEAE ALKALOIDS, LYCORINE AND ZEPHYRANTHINE
α-Onoceradiene-serratene isomerization and the configuration of serratenediol
Revised assignment of olefinic proton signals in the 1H-NMR spectra of dienoid-type erythrinan alkaloids
Previous assignment of the olefinic proton signals (H-1 and H-2) in the 1 H-nmr spectra of dienoid-type erythrinan alkaloids was interchanged on the basis of the synthesis of the stereoisomers, nOe… Expand
The synthesis of tetrahymanol.
Tritepenoid Chemistry. VII. Classification of Triterpenoid 1,3-Glycol Acetonides by NMR Spectra
Triterpenoid glycols carrying hydroxy-groups at C3 and at one of 4, 4-dimethyl groups were converted to the corresponding acetonides (A-D), whose characterization by nuclear magnetic resonance… Expand
Evaluation of neurotoxicity of TIQ and MPTP and of parkinsonism‐preventing effect of 1‐MeTIQ by in vivo measurement of pre‐synaptic dopamine transporters and post‐synaptic dopamine D2 receptors in…
- K. Ishiwata, Y. Koyanagi, +6 authors T. Sano
- Biology, Medicine
- Journal of neurochemistry
- 1 November 2001
It is concluded that the TIQ‐induced parkinsonism model is different from the MPTP‐induced model as evaluated by the radioligand‐DATs binding and that (S)‐1‐MeTIQ has a preventing effect for the degeneration of the DATs to a certain extent. Expand
Determination of Ring Conformation in 1-Benzyl-1,2,3,4-tetrahydroisoquinolines and a New Synthesis of the Chiral Compounds
The conformation of the piperideine ring in 1-benzyl-1, 2, 3, 4-tetrahydroisoquinolines was determined as 2H3 form with a pseudoaxial position of the 1-benzyl group by circular dichroism (CD)… Expand