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Solubilization and preformulation of carbendazim.
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A ‘Rule of Unity’ for Human Intestinal Absorption
TLDR
The ‘rule of 5’ and the ‘ rule of unity’ are compared using experimentally determined passive human intestinal absorption data for 155 drugs and striking differences in absorption predictability are revealed.
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Predicting Passive Intestinal Absorption Using A Single Parameter
TLDR
The model based on the new absorption parameter is shown to have wider applicability than current available models for predicting the fraction absorbed and to be validated using experimental human gastrointestinal absorption data for 98 compounds.
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Independence of the Product of Solubility and Distribution Coefficient of pH
TLDR
The fact that Sw⋅ Kow can be used instead of ST ⋅ KD to model the absorption of partially ionized drugs in the gastrointestinal tract has important biopharmaceutical implications.
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Estimation of Aqueous Solubility By The General Solubility Equation (GSE) The Easy Way
The General Solubility Equation (GSE) provides a simple method of estimating the molar aqueous solubility of an organic non-electrolyte in water (S w ) as a function of its celsius melting point (MP)…
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A Simple Modified Absorption Potential
TLDR
An absorption potential (AP) term is introduced for predicting the fraction of drug absorbed via passive transport, which is a dimensionless number and is defined as water solubility and partition coefficient.
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Estimation of the effect of NaCl on the solubility of organic compounds in aqueous solutions.
The Setschenow constant, K(salt), of a nonelectrolyte in a NaCl solution is shown to be related to the logarithm of its octanol-water partition coefficient, log K(ow), determined by K(salt) = A log…
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Formulation Development of Amorphous Dispersions
This chapter examines the development of clinical and commercial formulations of amorphous dispersions. It considers the various means available to render a crystalline drug amorphous. The chapter…
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The besylate salt of carbendazim: 2-(methoxy­carbonyl­amino)benzimidazolium benzene­sulfonate
In the title compound, C9H10N3O2+·C6H5O3S−, the asymmetric unit comprises a carbendazim cation and a besylate anion. Three inter­molecular N—H⋯O hydrogen bonds stabilize the structure.
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Translational Development of Amorphous Dispersions
This chapter demonstrates that the personnel involved in translational drug development (TDD) are integrated into each stage of discovery and development, serving as regular members of working…
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