Efficacy of olanzapine in acute bipolar mania: a double-blind, placebo-controlled study. The Olanzipine HGGW Study Group.
Olanzapine demonstrated greater efficacy than placebo in the treatment of acute bipolar mania and was generally well tolerated.
Olanzapine versus placebo and haloperidol: acute phase results of the North American double-blind olanzapine trial.
- C. Beasley, G. Tollefson, P. Tran, W. Satterlee, T. Sanger, S. Hamilton
- Psychology, MedicineNeuropsychopharmacology
The most common treatment-emergent adverse events included somnolence, agitation, asthenia, and nervousness.
Olanzapine treatment of psychotic and behavioral symptoms in patients with Alzheimer disease in nursing care facilities: a double-blind, randomized, placebo-controlled trial. The HGEU Study Group.
Low-dose olanzapine (5 and 10 mg/d) was significantly superior to placebo and well tolerated in treating agitation/aggression and psychosis in this population of patients with AD.
Olanzapine versus placebo in the treatment of acute mania
Olanzapine/fluoxetine combination for treatment-resistant depression: a controlled study of SSRI and nortriptyline resistance.
- R. Shelton, D. Williamson, G. Tollefson
- Psychology, MedicineThe Journal of clinical psychiatry
- 14 October 2005
The olanzapine/fluoxetine combination did not differ significantly from the other therapies at endpoint, although it demonstrated a more rapid response that was sustained until the end of treatment.
Olanzapine Plasma Concentrations and Clinical Response: Acute Phase Results of the North American Olanzapine Trial
- P. Perry, B. Lund, T. Sanger, C. Beasley
- Medicine, PsychologyJournal of Clinical Psychopharmacology
- 1 February 2001
A receiver operating characteristic (ROC) curve analysis of 12-hour olanzapine concentrations and treatment response from the North American Double-Blind Olanzapine Trial found a 12- hour olanZapine plasma concentration of >23.2 ng/mL was a predictor of therapeutic response in acutely ill patients with schizophrenia.
A randomized, double-blind comparison of olanzapine/fluoxetine combination, olanzapine, and fluoxetine in treatment-resistant major depressive disorder.
Patients with TRD (defined as treatment failure on 2 antidepressants) taking olanzapine/fluoxetine combination demonstrated significantly greater improvement in depressive symptoms than patients taking oanzapine or fluxetine in 1 of 2 studies and in the pooled analysis.
Olanzapine versus placebo: results of a double-blind, fixed-dose olanzapine trial
- C. Beasley, T. Sanger, W. Satterlee, G. Tollefson, P. Tran, S. Hamilton
- Medicine, PsychologyPsychopharmacology
- 1 March 1996
Olanzapine appears to be not only safe and effective, but a promising atypical antipsychotic candidate.
Olanzapine versus Placebo and Haloperidol