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Glucuronate-modified liposomes with prolonged circulation time.
- Y. Namba, T. Sakakibara, M. Masada, F. Ito, N. Oku
- Chemistry, Medicine
- Chemical & pharmaceutical bulletin
- 1 June 1990
For the purpose of obtaining liposomes with long circulation time in blood, we synthesized 1-O-palmityl-D-glucuronic acid (PGlcUA) and incorporated it into the liposomal membranes. The clearance of… Expand
SYNTHESES AND PROPERTIES OF NOVEL VINYL MONOMERS BEARING A GLYCOSIDE RESIDUE
Novel acrylic monomers bearing a monosaccharide residue were synthesized in reactions of some methyl glycosides with 2-hydroxylethyl acrylate or methacrylate in the presence of heteropoly acid. All… Expand
1-O-Palmityl-D-glucuronate Endows Liposomes with Long Half-Life In Vivo
More liposomes containing 1-O-palmityl-D-glucuronic acid (PGA), a synthetic glycolipid, bound to macrophages than those containing phosphatidylglycerol did in vitro; however, PGA-liposomes circulated… Expand
Liposomal modification with uronate, which endows liposomes with long circulation in vivo, reduces the uptake of liposomes by J774 cells in vitro.
For overcoming rapid removal of liposomes from the bloodstream, we developed reticuloendothelial system (RES)-avoiding liposomes modified with a uronic acid derivative, palmityl-D-glucuronide… Expand
Properties of mixed monolayers of DPPC and viscoelasticity-giving substances
Abstract Static surface pressures and dynamic surface pressures for the mixed monolayers consisting of dipalmitoylphosphatidylcholine (DPPC), cholesterol linoleate (Cho-Linoleate), stearyl alcohol… Expand
Potential Application of Some Synthetic Glycosides to Food Modification
Studies on the Water-Soluble Polymers XIV
Polyacrylamide was reacted with hydrazine hydrate to give polyacrylic hydrazide. Analysis of polyacrylic hydrazide was investigated, and a method of quantitative analysis was established by using… Expand
Reactions of Dihydroxybenzene Derivatives with Formaldehyde
酸性触媒で Ar(OCH2CH2X) (Ar : o-, m-, p-フェニレン-, X=CN, OH) とホルムアルデヒ2ドを反応させ, DMF などの有機溶媒に可溶の分子量 1000～9000 の樹脂を得た。本報では過塩素酸を触媒とし, 酢酸溶媒中 30.0℃ で反応を行ない, 反応時間, 触媒量, 溶媒量,… Expand
Preparation of Liposome Using Instantaneous Vacuum-Dried Lipid Mixture
A new method was developed for preparing liposomes using an instananeous vacuum-dried lipid mixture. White lipid powder for preparing liposomes was easily obtained by spraying an organic solution of… Expand