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Amygdalar neuropeptide Y Y1 receptors mediate the anxiolytic-like actions of neuropeptide Y in the social interaction test.
Corticotrophin Releasing Factor-Induced Synaptic Plasticity in the Amygdala Translates Stress into Emotional Disorders
- D. Rainnie, R. Bergeron, T. Sajdyk, M. Patil, D. Gehlert, A. Shekhar
- Biology, PsychologyThe Journal of Neuroscience
- 7 April 2004
Results show for the first time a stress peptide-induced behavioral syndrome that can be correlated with cellular mechanisms of neural plasticity, a novel mechanism that may explain the etiological role of stress in several chronic psychiatric and medical disorders.
Role of corticotropin-releasing factor and urocortin within the basolateral amygdala of rats in anxiety and panic responses
Neuropeptide Y receptor subtypes in the basolateral nucleus of the amygdala modulate anxiogenic responses in rats
Interactions between NPY and CRF in the amygdala to regulate emotionality
Role of stress, corticotrophin releasing factor (CRF) and amygdala plasticity in chronic anxiety
The hypotheses that stress induced plasticity within the amygdala may be a critical step in the pathophysiology of the development of chronic anxiety states are summarized.
Neuropeptide Y-Y2 receptors mediate anxiety in the amygdala
Excitatory amino acid receptors in the basolateral amygdala regulate anxiety responses in the social interaction test
The role of neuropeptide Y in the amygdala on corticotropin-releasing factor receptor-mediated behavioral stress responses in the rat
Results showed that injections of NPY into the BLA prior to Ucn significantly blocked the development of the avoidance behavior in the two floor choice test and the decrease in SI time that is usually seen following restraint stress, providing further support that an interaction between NPY and CRF within theBLA may be critical for maintaining a normal homeostatic emotional state.
The Amygdala, Panic Disorder, and Cardiovascular Responses
- A. Shekhar, T. Sajdyk, D. Gehlert, D. Rainnie
- Biology, PsychologyAnnals of the New York Academy of Sciences
- 1 April 2003
The results suggest that the BLA has a significant role in regulating anxiety, autonomic responses, and the development of anxiety disorders.