T. Saitoh

Publications125
h-index46
Citations15,860
Highly Influential Citations854
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Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production
Systems for protein degradation are essential for tight control of the inflammatory immune response. Autophagy, a bulk degradation system that delivers cytoplasmic constituents into autolysosomes,… Expand
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Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages
Beclin 1, a protein essential for autophagy, binds to hVps34/Class III phosphatidylinositol-3-kinase and UVRAG. Here, we have identified two Beclin 1 associated proteins, Atg14L and Rubicon. Atg14L… Expand
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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the… Expand
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  • 47
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The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection
Polarization of macrophages to M1 or M2 cells is important for mounting responses against bacterial and helminth infections, respectively. Jumonji domain containing-3 (Jmjd3), a histone 3 Lys27… Expand
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Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response.
Microbial nucleic acids are critical for the induction of innate immune responses, a host defense mechanism against infection by microbes. Recent studies have indicated that double-stranded DNA… Expand
  • 497
  • 44
Autophagy in infection, inflammation and immunity
Autophagy is a fundamental eukaryotic pathway that has multiple effects on immunity. Autophagy is induced by pattern recognition receptors and, through autophagic adaptors, it provides a mechanism… Expand
  • 1,132
  • 43
Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response
Microbial nucleic acids are critical for the induction of innate immune responses, a host defense mechanism against infection by microbes. Recent studies have indicated that double-stranded DNA… Expand
  • 492
  • 43
  • PDF
Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome
NLRP3 forms an inflammasome with its adaptor ASC, and its excessive activation can cause inflammatory diseases. However, little is known about the mechanisms that control assembly of the inflammasome… Expand
  • 474
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Sequential control of Toll-like receptor–dependent responses by IRAK1 and IRAK2
Members of the IRAK family of kinases mediate Toll-like receptor (TLR) signaling. Here we show that IRAK2 was essential for sustaining TLR-induced expression of genes encoding cytokines and… Expand
  • 382
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Autophagy requires endoplasmic reticulum targeting of the PI3-kinase complex via Atg14L
Generation of PI3P in the normally PI3P-deficient ER membrane makes the organelle a platform for autophagosome formation.
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