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Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2
RIG-I is an RNA helicase containing caspase activation and recruitment domains (CARDs). RNA binding and signaling by RIG-I are implicated in pathogen recognition and triggering of IFN-α/β immuneExpand
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Innate immunity induced by composition-dependent RIG-I recognition of hepatitis C virus RNA
Innate immune defences are essential for the control of virus infection and are triggered through host recognition of viral macromolecular motifs known as pathogen-associated molecular patternsExpand
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Viral and therapeutic control of IFN-beta promoter stimulator 1 during hepatitis C virus infection.
  • Y. Loo, D. Owen, +15 authors M. Gale
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 11 April 2006
Viral signaling through retinoic acid-inducible gene-I (RIG-I) and its adaptor protein, IFN promoter-stimulator 1 (IPS-1), activates IFN regulatory factor-3 (IRF-3) and the host IFN-alpha/betaExpand
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RNase L releases a small RNA from HCV RNA that refolds into a potent PAMP.
Triggering and propagating an intracellular innate immune response is essential for control of viral infections. RNase L is a host endoribonuclease and a pivotal component of innate immunity thatExpand
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A systematic review on silver nanoparticles-induced cytotoxicity: Physicochemical properties and perspectives
Abstract With the development of nanotechnology, silver nanoparticles (Ag-NPs) have become one of the most in-demand nanoparticles owing to their exponential number of uses in various sectors.Expand
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Rapid simultaneous determination for organophosphorus pesticides in human serum by LC-MS.
A simple and rapid method was developed for measuring 10 organophosphorus pesticides (acephate, methidathion, dichlorvos, fenthion, EPN, diazinon, phenthoate, malathion, fenitrothion, and cyanophos)Expand
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Innate immune tolerance and the role of kupffer cells in differential responses to interferon therapy among patients with HCV genotype 1 infection.
BACKGROUND & AIMS In patients with hepatitis C virus (HCV) infection, interferon alfa (IFN-α) alters expression of IFN-stimulated genes (ISGs), but little is understood about factors that determineExpand
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Differential recognition of double-stranded RNA by RIG-I–like receptors in antiviral immunity
  • T. Saito, M. Gale
  • Biology, Medicine
  • The Journal of experimental medicine
  • 7 July 2008
Retinoic acid–inducible gene (RIG)-I–like receptors (RLRs) are cytosolic RNA helicases that sense viral RNA and trigger signaling pathways that induce the production of type I interferons (IFNs) andExpand
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Early hemoperfusion with an immobilized polymyxin B fiber column eliminates humoral mediators and improves pulmonary oxygenation
IntroductionThe objective of this study was to clarify the efficacy and mechanism of action of direct hemoperfusion with an immobilized polymyxin B fiber column (DHP-PMX) in patients with acute lungExpand
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A fatal case of MAM-2201 poisoning
A 59-year-old man was found dead in his house, where three sachets containing herbal blends were found on a table. The sachet contents were analyzed by gas chromatography–mass spectrometry and foundExpand
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