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Antiproliferative constituents in Umbelliferae plants II. Screening for polyacetylenes in some Umbelliferae plants, and isolation of panaxynol and falcarindiol from the root of Heracleum
Panaxynol and falcarindiol were successfully isolated from the root of Heracleum moellendorffii as antiproliferative polyacetylenes.
Potentiation of cytotoxicity of mitomycin C bt a polyacetylenic alcohol, panaxytriol
Results suggest that synergistic effects of panaxytriol and MMC may be induced by acceleration of the effect of MMC on cellular that the enhanced accumulation in MK-1 cells treated with panaxyTriol can probably be attributed to the decreased fluidity of the cell membrane caused by panaxy triol.
The first specific antibody against cytotoxic polyacetylenic alcohol, panaxynol.
The first specific antibody production against panaxynol is demonstrated, which may be a valuable tool for studies of the biological properties of polyacetylenic compounds.
Immunocytochemistry for Vancomycin Using a Monoclonal Antibody That Reveals Accumulation of the Drug in Rat Kidney and Liver
Double fluorescence staining using rats simultaneously administered with VM and gentamicin strongly suggests that both drugs colocalized in lysosomes in the proximal tubule cells of kidneys.
A highly sensitive enzyme-linked immunosorbent assay (ELISA) for antitumor polyacetylenic alcohol, panaxytriol.
A highly sensitive enzyme-linked immunosorbent assay (ELISA) for the determination of panaxytriol was developed, which is capable of measuring as low as 25.6 pg/ml, and may be a valuable tool for studies of the biological and pharmacological properties of the polyacetylenic alcohol, panaxyTriol.
Enzyme immunoassay for the quantification of mithramycin using beta-D-galactosidase as a label.
A sensitive enzyme immunoassay for mithramycin (MTM) has been developed by using antibody induced in rabbits, beta-D-galactosidase-labeled MTM, and a double-antibody separation technique, which
Development of a specific and sensitive enzyme-linked immunosorbent assay for the quantification of imatinib.
The specificity and sensitivity of the ELISA forImatinib should provide a valuable new tool for use in therapeutic drug monitoring and pharmacokinetic studies of imatinib.