• Publications
  • Influence
Antitumor agents, 119. Kansuiphorins A and B, two novel antileukemic diterpene esters from Euphorbia kansui.
TLDR
The extract of the roots of Euphorbia kansui demonstrated antileukemic activity against the P-388 lymphocytic leukemia in mice and the selectivity of kansuiphorin A, which inhibits the growth of particular cell types within the disease-oriented human cancer cell line panels, is discussed. Expand
Anti-inflammatory and analgesic activities from roots of Angelica pubescens.
TLDR
The results revealed that the anti-inflammatory and analgesic constituents from roots of AP were related to peripheral inhibition of inflammatory substances and to the influence on the central nervous system. Expand
Aristolochic acids, aristolactam alkaloids and amides from Aristolochia kankauensis.
TLDR
Ariskanins-A-E and N-p-cis-coumaroyltyramine are reported for the first time from a natural source and the cytotoxicity and antiplatelet activity of the compounds isolated are discussed. Expand
Pharmacological characterization of cinnamophilin, a novel dual inhibitor of thromboxane synthase and thromboxane A2 receptor
TLDR
It is concluded that cinnamophilin is a novel dual TX synthase inhibitor and TXA2 receptor antagonist and that it may be a useful tool for the investigation and treatment of diseases involving TXA 2 disorders. Expand
Cytotoxicity of Ganoderma lucidum triterpenes.
TLDR
Two new triterpenoids, lucidenic acid N and methyl lucidenate F, and ganoderic acid E, were isolated from the dried fruiting bodies of Ganoderma lucidum and showed significant cytotoxic activity against HepG2, Hep G2,2,15, and P-388 tumor cells. Expand
New constituents and antiplatelet aggregation and anti-HIV principles of Artemisia capillaris.
Five new constituents including a flavonoid, artemisidin A (1), and four coumarins, artemicapins A (2), B (3), C (4) and D (5), together with 70 known compounds (6-75), have been isolated andExpand
Vasorelaxation of rat thoracic aorta caused by osthole isolated from Angelica pubescens.
TLDR
It is concluded that osthole relaxes rat thoracic aorta by virtue of its Ca(2+)-channel blocking properties and by elevating cGMP levels in vascular smooth muscle. Expand
Cinnamophilin, a novel thromboxane A2 receptor antagonist, isolated from Cinnamomum philippinense.
TLDR
Results indicate that cinnamophilin is a selective thromboxane A2 receptor antagonist especially in rat aorta, and also possesses voltage-dependent Ca2+ channel blocking properties. Expand
An antiplatelet aggregation principle and X-ray structural analysis of cis-khellactone diester from Peucedanum japonicum.
TLDR
Three structurally related khellactone coumarins, 1-3, were isolated from the aerial parts of Peucedanum japonicum and subjected to the antiplatelet aggregation bioassay where cis-3',4'-diisovalerylkhellact one showed significant activity. Expand
Synthesis and cytotoxicity of 1,6,7,8-substituted 2-(4'-substituted phenyl)-4-quinolones and related compounds: identification as antimitotic agents interacting with tubulin.
TLDR
Compounds 24, 26, and 27 were potent inhibitors of tubulin polymerization, with activity nearly comparable to that of the potent antimitotic natural products colchicine, podophyllotoxin, and combretastatin A-4. Expand
...
1
2
3
4
5
...