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Understanding Hydrogen Sulfide Storage: Probing Conditions for Sulfide Release from Hydrodisulfides
Hydrogen sulfide (H2S) is an important biological signaling agent that exerts action on numerous (patho)physiological processes. Once generated, H2S can be oxidized to generate reductant-labileExpand
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Chemiluminescent detection of enzymatically produced hydrogen sulfide: substrate hydrogen bonding influences selectivity for H2S over biological thiols.
Hydrogen sulfide (H2S) is now recognized as an important biological regulator and signaling agent that is active in many physiological processes and diseases. Understanding the important roles ofExpand
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Reactions of isolated persulfides provide insights into the interplay between H2S and persulfide reactivity.
Hydrogen sulfide is ubiquitous in biological systems and exerts function over a wide range of important physiological processes. Complementing free H2S, the reductant-labile sulfur pool playsExpand
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Natural Products Containing Hydrogen Sulfide Releasing Moieties
Hydrogen sulfide (H2S) is now recognized as an important biological molecule that plays diverse roles in various (patho)physiological conditions. Endogenous H2S, or its misregulation, has beenExpand
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Variation in the pH-dependent pre-steady-state and steady-state kinetic characteristics of cysteine-proteinase mechanism: evidence for electrostatic modulation of catalytic-site function by the
The acylation and deacylation stages of the hydrolysis of N -acetyl-Phe-Gly methyl thionoester catalysed by papain and actinidin were investigated by stopped-flow spectral analysis. Differences inExpand
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The Intersection of NO and H2S: Persulfides Generate NO from Nitrite through Polysulfide Formation.
Hydrogen sulfide (H2S) and nitric oxide (NO) are important biosignaling molecules, and their biochemistries are increasingly recognized to be intertwined. Persulfides are an oxidized product ofExpand
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Variation in aspects of cysteine proteinase catalytic mechanism deduced by spectroscopic observation of dithioester intermediates, kinetic analysis and molecular dynamics simulations.
The possibility of a slow post-acylation conformational change during catalysis by cysteine proteinases was investigated by using a new chromogenic substrate, N-acetyl-Phe-Gly methyl thionoester,Expand
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A simple bioluminescent method for measuring d-amino acid oxidase activity† †Electronic supplementary information (ESI) available: Experimental methods, UV-vis data. See DOI: 10.1039/c4cc08145e Click
A bioluminescent method for measuring d-amino acid oxidase (DAO) activity was developed based on the luciferin/luciferase reporting platform.
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Chemical Tools for Studying Biological Hydrogen Sulfide
Although hydrogen sulfide (H2S) has historically been recognized as a toxic gas, recent studies have established H2S as an important, endogenously-produced signaling molecule active in a wide arrayExpand
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