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Metabolic regulation in the lactating mammary gland: a lipid synthesizing machine.
TLDR
Results show that substantial regulation of lipid synthesis occurs at the level of mRNA expression and that some of the regulation points differ substantially from the liver, and implicate the transcription factor SREBP-1c in regulation of part of the pathway. Expand
Molecular Determinants of Milk Lipid Secretion
TLDR
Advances in the understanding of the molecular, structural, and functional properties of these proteins now make it possible to understand the physiological functions of each of these molecules in detail and to identify the specific molecular determinants that mediate milk lipid secretion. Expand
Cytoplasmic lipid droplet accumulation in developing mammary epithelial cells: roles of adipophilin and lipid metabolism Published, JLR Papers in Press, April 23, 2007.
TLDR
Evidence is presented that the epithelial and adipose compartments of the mammary gland undergo concerted, developmentally regulated shifts in lipid metabolism that increase the availability of fatty acids necessary for lipid synthesis by milk-secreting cells. Expand
Multiple functions encoded by the N-terminal PAT domain of adipophilin
TLDR
The results suggest that the N-terminal region of ADPH mediates proteasomal degradation and access of TIP47 to the CLD surface and possibly contributes to CLD stability. Expand
Transduction of the Mammary Epithelium with Adenovirus Vectors In Vivo
TLDR
The results demonstrate that intraductal injection of adenovirus vectors provides a versatile and noninvasive method of investigating genes of interest in mouse mammary epithelial cells. Expand
Impaired tight junction sealing and precocious involution in mammary glands of PKN1 transgenic mice
TLDR
Evidence is provided that PKN1 participates in the regulation of tight junction sealing in the mammary gland by interfering with glucocorticoid signaling. Expand
Myoepithelial cell differentiation markers in ductal carcinoma in situ progression.
We describe a preclinical model that investigates progression of early-stage ductal carcinoma in situ (DCIS) and report that compromised myoepithelial cell differentiation occurs before transition toExpand
Adipophilin regulates maturation of cytoplasmic lipid droplets and alveolae in differentiating mammary glands
TLDR
Comparisons in differentiating mammary glands of wild-type and ADPH-deficient mice provide direct in vivo evidence that ADPH inhibition of ATGL-dependent lipolysis is required for normal CLD accumulation and alveolar maturation during mammary gland differentiation. Expand
Claudin 7 expression and localization in the normal murine mammary gland and murine mammary tumors
TLDR
Observations suggest that claudin 7 might be involved in vesicle trafficking to the basolateral membrane, possibly stabilizing cytoplasmic vesicles or participating in cell–matrix interactions. Expand
Prolactin-mediated regulation of lipid biosynthesis genes in vivo in the lactating mammary epithelial cell.
TLDR
Prolactin signaling regulates MEC-specific lipogenic gene expression and that PRL signals coordinate the milk synthesis and mammary epithelial cell survival during lactation in the mouse is demonstrated. Expand
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