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Structural Basis of the Interaction of the Pyelonephritic E. coli Adhesin to Its Human Kidney Receptor
PapG is the adhesin at the tip of the P pilus that mediates attachment of uropathogenic Escherichia coli to the uroepithelium of the human kidney. The human specific allele of PapG binds to globosideExpand
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Interaction of Calcium with Bordetella pertussis Adenylate Cyclase Toxin
The adenylate cyclase (CyaA) secreted by Bordetella pertussis is a toxin that is able to enter eukaryotic cells and cause a dramatic increase in cAMP level. In addition, the toxin also exhibits anExpand
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Molecular mapping of thrombin-receptor interactions.
In addition to its procoagulant and anticoagulant roles in the blood coagulation cascade, thrombin works as a signaling molecule when it interacts with the G-protein coupled receptors PAR1, PAR3, andExpand
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Identification and Biochemical Characterization of Human Plasma Soluble IL-7R: Lower Concentrations in HIV-1-Infected Patients1
The IL-7R α-chain and the common γ-chain (γc) are both components of IL-7R. Human plasma harbors soluble forms of IL-7R (sIL-7Rα and sγc) that are detected and assayed by Western blotting, showingExpand
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A Programmed Switch from IL-15- to IL-2-Dependent Activation in Human NK Cells1
IL-2 and IL-15 differentially control the development, activation and proliferation of human NK cells, although they share common signal-transducing receptor chains CD122 and common γ. To exploreExpand
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Molecular Basis of Ion Selectivity, Block, and Rectification of the Inward Rectifier Kir3.1/Kir3.4 K+ Channel
The glycine-tyrosine-glycine (GYG) sequence in the p-loop of K+ channel subunits lines a narrow pore through which K+ ions pass in single file intercalated by water molecules. Mutation of the motifExpand
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IL-2 induces conformational changes in its preassembled receptor core, which then migrates in lipid raft and binds to the cytoskeleton meshwork.
While interleukin (IL)-2 clearly initiates the sequential assembly of its soluble receptor fragments (sIL-2R) in vitro (with sIL-2Rα first, sIL-2Rβ second, and sγc last), the assembly mechanism ofExpand
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Interleukin (IL)-2 and IL-15 have different effects on human natural killer lymphocytes.
Although interleukin (IL)-2 and IL-15 share the common signal transducing receptor chains IL-2Rβ and γ(c) and give rise to the same signaling patterns in human natural killer (NK) cells in vitro,Expand
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In vitro identification of the cytochrome P450 isoform responsible for the metabolism of a-dihydroergocryptine
1. The in vitro metabolism of a-dihydroergocryptine (DHEC, Almirid®), an ergot-derived dopamine agonist for the treatment of Parkinson's disease, has been studied in cultured cell lines followingExpand
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Nonprecious alloys for use in fixed prosthodontics: a literature review.
  • J. R. Kelly, T. Rose
  • Materials Science, Medicine
  • The Journal of prosthetic dentistry
  • 1 March 1983
The physical properties of nonprecious alloys can differ significantly from those of alloys containing a high percent of gold. Relationships among constituents, physical properties, and handlingExpand
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