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The pgaABCD locus of Escherichia coli promotes the synthesis of a polysaccharide adhesin required for biofilm formation.
Production of a polysaccharide matrix is a hallmark of bacterial biofilms, but the composition of matrix polysaccharides and their functions are not widely understood. Previous studies of theExpand
The RNA Molecule CsrB Binds to the Global Regulatory Protein CsrA and Antagonizes Its Activity in Escherichia coli *
The RNA-binding protein CsrA (carbon storage regulator) is a new kind of global regulator, which facilitates specific mRNA decay. A recombinant CsrA protein containing a metal-binding affinity tagExpand
Global regulation by the small RNA‐binding protein CsrA and the non‐coding RNA molecule CsrB
  • T. Romeo
  • Biology, Medicine
  • Molecular microbiology
  • 1 September 1998
Csr (carbon storage regulator) is a recently discovered global regulatory system that controls bacterial gene expression post‐transcriptionally. Its effector is a small RNA‐binding protein referredExpand
A novel sRNA component of the carbon storage regulatory system of Escherichia coli
Small untranslated RNAs (sRNAs) perform a variety of important functions in bacteria. The 245 nucleotide sRNA of Escherichia coli, CsrC, was discovered using a genetic screen for factors thatExpand
Positive regulation of motility and flhDC expression by the RNA‐binding protein CsrA of Escherichia coli
Many species of bacteria devote considerable metabolic resources and genetic information to the ability to sense the environment and move towards or away from specific stimuli using flagella. InExpand
CsrB sRNA family: sequestration of RNA-binding regulatory proteins.
Noncoding regulatory RNA molecules, also known as small RNAs, participate in several bacterial regulatory networks. The central component of the carbon storage regulator (Csr) and the homologousExpand
Identification of a novel regulatory protein (CsrD) that targets the global regulatory RNAs CsrB and CsrC for degradation by RNase E.
In Escherichia coli, the global regulatory protein CsrA (carbon store regulator A) binds to leader segments of target mRNAs, affecting their translation and stability. CsrA activity is regulated byExpand
Identification and molecular characterization of csrA, a pleiotropic gene from Escherichia coli that affects glycogen biosynthesis, gluconeogenesis, cell size, and surface properties.
Current evidence suggests that a few global regulatory factors mediate many of the extensive changes in gene expression that occur as Escherichia coli enters the stationary phase. One of theExpand
Biofilm formation and dispersal under the influence of the global regulator CsrA of Escherichia coli.
The predominant mode of growth of bacteria in the environment is within sessile, matrix-enclosed communities known as biofilms. Biofilms often complicate chronic and difficult-to-treat infections byExpand
Post-transcriptional regulation on a global scale: form and function of Csr/Rsm systems.
Originally described as a repressor of gene expression in the stationary phase of growth, CsrA (RsmA) regulates primary and secondary metabolic pathways, biofilm formation, motility, virulenceExpand
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