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The neural basis of drug craving: An incentive-sensitization theory of addiction
S sensitization of incentive salience can produce addictive behavior even if the expectation of drug pleasure or the aversive properties of withdrawal are diminished and even in the face of strong disincentives, including the loss of reputation, job, home and family. Expand
What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?
It is suggested that dopamine may be more important to incentive salience attributions to the neural representations of reward-related stimuli and is a distinct component of motivation and reward. Expand
Enduring changes in brain and behavior produced by chronic amphetamine administration: A review and evaluation of animal models of amphetamine psychosis
There is not convincing evidence for an increase in postsynaptic DA receptors or in DA synthesis in animals sensitized to AMPH, but there is strong evidence to support the notion that behavioral sensitization is due to enhanced mesotelencephalic DA release, especially upon re-exposure to the drug. Expand
The incentive sensitization theory of addiction: some current issues
  • T. Robinson, K. Berridge
  • Psychology, Medicine
  • Philosophical Transactions of the Royal Society B…
  • 12 October 2008
The theory that addiction is caused primarily by drug-induced sensitization in the brain mesocorticolimbic systems that attribute incentive salience to reward-associated stimuli is presented. Expand
Dissecting components of reward: 'liking', 'wanting', and learning.
Findings on three dissociable psychological components of reward: 'liking' (hedonic impact), 'wanting' (incentive salience), and learning (predictive associations and cognitions) are highlighted. Expand
Structural plasticity associated with exposure to drugs of abuse
Evidence is summarized that exposure to amphetamine, cocaine, nicotine or morphine produces persistent changes in the structure of dendrites and dendritic spines on cells in brain regions involved in incentive motivation and reward, and judgment and the inhibitory control of behavior. Expand
The psychology and neurobiology of addiction: an incentive-sensitization view.
It is argued that traditional negative reinforcement, positive reinforcement, and hedonic accounts of addiction are neither necessary nor sufficient to account for compulsive patterns of drug-seeking and drug-taking behavior. Expand
Incentive-sensitization and addiction.
This paper summarizes one view of the process by which drug-taking behavior evolves into compulsive patterns of drug-seeking and drug- taking behavior that take place at the expense of most other activities, and describes the critical neuroadaptations for addiction. Expand
Parsing reward
It is argued that further advances in the neuroscience of reward will require equal sophistication in parsing reward into its specific psychological components: learning, affect or emotion, motivation and how these components interact. Expand