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Neural systems of reinforcement for drug addiction: from actions to habits to compulsion
TLDR
It is hypothesized that the change from voluntary drug use to more habitual and compulsive drug use represents a transition at the neural level from prefrontal cortical to striatal control over drug seeking and drug taking behavior as well as a progression from ventral to more dorsal domains of the striatum, involving its dopaminergic innervation. Expand
Inhibition and the right inferior frontal cortex
TLDR
Advances in human lesion-mapping support the functional localization of such inhibition to right IFC alone, and future research should investigate the generality of this proposed inhibitory function to other task domains, and its interaction within a wider network. Expand
Dissociation in prefrontal cortex of affective and attentional shifts
TLDR
It is demonstrated that disinhibition, or a loss of inhibitory control, can be selective for particular cognitive functions and that different regions of the prefrontal cortex provide inhibitory Control in different aspects of cognitive processing. Expand
Inhibition and impulsivity: Behavioral and neural basis of response control
TLDR
This review will review the current models of behavioral inhibition along with their expression via underlying brain regions, including those involved in the activation of the brain's emergency 'brake' operation, those engaged in more controlled and sustained inhibitory processes and other ancillary executive functions. Expand
Stop-signal inhibition disrupted by damage to right inferior frontal gyrus in humans
TLDR
This work uses a new observer-independent method to relate the degree of damage within a specific prefrontal region to performance on a stop-signal task that is sensitive to the neurodevelopmental aspects of stopping behavior and to attention-deficit/hyperactivity disorder (ADHD) as well as its amelioration by methylphenidate. Expand
Putting a spin on the dorsal–ventral divide of the striatum
TLDR
This review presents a synthesis between the dorsal-ventral distinction and the more mediolateral-oriented functional striatal gradient. Expand
Choosing between Small, Likely Rewards and Large, Unlikely Rewards Activates Inferior and Orbital Prefrontal Cortex
TLDR
The results suggest that decision making recruits neural activity from multiple regions of the inferior PFC that receive information from a diverse set of cortical and limbic inputs, and that the contribution of the orbitofrontal regions may involve processing changes in reward-related information. Expand
Impulsivity, Compulsivity, and Top-Down Cognitive Control
TLDR
The results indicate that the vulnerability to stimulant addiction may depend on an impulsivity endophenotype, and characterize in neurobehavioral and neurochemical terms a rodent model of impulsivity based on premature responding in an attentional task. Expand
Inhibition and the right inferior frontal cortex: one decade on
TLDR
It is proposed that the rIFC (along with one or more fronto-basal-ganglia networks) is best characterized as a brake, and this brake can be turned on in different modes and in different contexts. Expand
Enhanced or impaired cognitive function in Parkinson's disease as a function of dopaminergic medication and task demands.
TLDR
DA-ergic medication improves or impairs cognitive performance depending on the nature of the task and the basal level of DA function in underlying cortico-striatal circuitry, which is relatively spared of DA loss in PD. Expand
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