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A new, semi-structured psychiatric interview for use in genetic linkage studies: a report on the reliability of the SSAGA.
Although SSAGA was designed to provide for broad phenotyping of alcoholism, review of its new features suggests its suitability for a variety of family studies, not just those focusing on substance abuse.
Subgenual prefrontal cortex abnormalities in mood disorders
Using positron emission tomographic images of cerebral blood flow and rate of glucose metabolism to measure brain activity, an area of abnormally decreased activity is localized in the pre-frontal cortex ventral to the genu of the corpus callosum in both familial bipolar depressives and familial unipolar depressives.
Diagnostic interview for genetic studies. Rationale, unique features, and training. NIMH Genetics Initiative.
The DIGS is designed to be employed by interviewers who exercise significant clinical judgment and who summarize information in narrative form as well as in ratings, and should be useful as part of archival data gathering for genetic studies of major affective disorders, schizophrenia, and related conditions.
Genome-wide search for genes affecting the risk for alcohol dependence.
There was suggestive evidence for a protective locus on chromosome 4 near the alcohol dehydrogenase genes, for which protective effects have been reported in Asian populations.
Variations in GABRA2, encoding the alpha 2 subunit of the GABA(A) receptor, are associated with alcohol dependence and with brain oscillations.
The very strong association of GABRA2 with both alcohol dependence and the beta frequency of the electroencephalogram, combined with biological evidence for a role of this gene in both phenotypes, suggest that GABra2 might influence susceptibility to alcohol dependence by modulating the level of neural excitation.
Comparison of direct interview and family history diagnoses of alcohol dependence.
A recursive equation is derived to combine a variable number of family history reports, wherein the probabilities associated with a single report are computed from the logistic analysis, which permits the use offamily history information both as a proxy for an uninterviewed relative, as well as a second source of information to be used in the analysis of genetic family data.
A perspective on epistasis: limits of models displaying no main effect.
- R. Culverhouse, B. Suarez, Jennifer H. Lin, T. Reich
- BiologyAmerican journal of human genetics
- 1 February 2002
This article examines a large class of genetic models, delimiting the range of genetic determination and recurrence risks for two-, three-, and four-locus purely epistatic models, and reveals that these models, although giving rise to no additive or dominance variation, give rise to increased allele sharing between affected sibs.
Familial transmission of substance dependence: alcohol, marijuana, cocaine, and habitual smoking: a report from the Collaborative Study on the Genetics of Alcoholism.
Alcohol, marijuana, and cocaine dependence and habitual smoking are all familial, and there is evidence of both common and specific addictive factors transmitted in families.
Genetic heterogeneity and the classification of alcoholism.
- C. R. Cloninger, S. Sigvardsson, S. Gilligan, A. von Knorring, T. Reich, M. Bohman
- Psychology, MedicineAdvances in alcohol & substance abuse
- 1 March 1988
Empirical findings about sex differences, ages of onset, associated personality traits, and longitudinal course are described in a series of adoption and family studies in Sweden and the United States.
Evidence of common and specific genetic effects: association of the muscarinic acetylcholine receptor M2 (CHRM2) gene with alcohol dependence and major depressive syndrome.
Findings provide strong evidence that variants within or close to the CHRM2 locus influence risk for two common psychiatric disorders.