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Structural and kinetic determinants of protease substrates
Two fundamental questions with regard to proteolytic networks and pathways concern the structural repertoire and kinetic threshold that distinguish legitimate signaling substrates. We used N-terminalExpand
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Replicable and Coupled Changes in Innate and Adaptive Immune Gene Expression in Two Case-Control Studies of Blood Microarrays in Major Depressive Disorder
Background Peripheral inflammation is often associated with major depressive disorder (MDD), and immunological biomarkers of depression remain a focus of investigation. Methods We used microarrayExpand
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Immune Cell Gene Signatures for Profiling the Microenvironment of Solid Tumors
ImSig is a resource of gene signatures for the quantitative and qualitative assessment of immune cells in the tumor microenvironment. It can be used on other tissue pathologies and identifying theExpand
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Assembly of a parts list of the human mitotic cell cycle machinery
Abstract The set of proteins required for mitotic division remains poorly characterized. Here, an extensive series of correlation analyses of human and mouse transcriptomics data were performed toExpand
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Pleiotropic Impacts of Macrophage and Microglial Deficiency on Development in Rats with Targeted Mutation of the Csf1r Locus
We have produced Csf1r-deficient rats by homologous recombination in embryonic stem cells. Consistent with the role of Csf1r in macrophage differentiation, there was a loss of peripheral bloodExpand
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Infrared Spectroscopy of EnzymeReaction Intermediates
The serine proteinase mechanism has been studied using a wide range of techniques over many years and is now well understood in terms of the formal chemical changes that occur on the reactionExpand
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Characterisation of the British honey bee metagenome
The European honey bee (Apis mellifera) plays a major role in pollination and food production. Honey bee health is a complex product of the environment, host genetics and associated microbesExpand
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Characterisation of the UK honey bee (Apis mellifera) metagenome
The European honey bee (Apis mellifera) plays a major role in pollination and food production, but is under threat from emerging pathogens and agro-environmental insults. As with other organisms,Expand
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A Machine Learning Approach to Understanding Patterns of Engagement With Internet-Delivered Mental Health Interventions.
Importance The mechanisms by which engagement with internet-delivered psychological interventions are associated with depression and anxiety symptoms are unclear. Objective To identify behaviorExpand
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Characterisation of the UK honey bee metagenome
Publisher Rights Statement: Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproductionExpand
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