• Publications
  • Influence
DNA methylation and hepatocarcinogenesis in rats fed a choline-devoid diet.
TLDR
Undermethylation of liver total DNA is a late effect of dietary choline deficiency in the rat, and is found in three of four hepatocellular carcinomas found in rats killed at 14 months. Expand
Biological markers of exposure to benzene: S-phenylcysteine in albumin.
TLDR
It is concluded that SPC in albumin may prove useful as a biomarker for benzene exposure. Expand
17α‐ethynylestradiol‐induced vitellogenin gene transcription quantified in livers of adult males, larvae, and gills of fathead minnows (Pimephales promelas)
TLDR
Use of the model provides sensitivity of detection at a concentration below those that cause mortality or visible signs of stress in fish or other aquatic organisms, and may provide an in vivo screening method for estrogenlike endocrine-disrupting compounds. Expand
17alpha-ethynylestradiol-induced vitellogenin gene transcription quantified in livers of adult males, larvae, and gills of fathead minnows (Pimephales promelas).
TLDR
Use of the model provides sensitivity of detection at a concentration below those that cause mortality or visible signs of stress in fish or other aquatic organisms, and may provide an in vivo screening method for estrogenlike endocrine-disrupting compounds. Expand
Mutagenicity of urine from rats after administration of 2,4-diaminoanisole: the effect of microsomal enzyme inducers.
TLDR
The mutagenicity pattern for urine in vitro was shown to be similar with liver S9 from rats induced either with Aroclor 1254 or with MC, and the number of revertants was almost doubled in the presence of an activating system. Expand
Assessment of environmental hazards of 1,3,5-trinitrobenzene.
TLDR
Based on the newly determined NOAEL and LOAEL values, a new RfD for TNB is developed, based on the chronic toxic effects on hematology and histopathological changes in testes and kidney, for subchronic, chronic, reproductive, and developmental toxicity. Expand
Hepatocarcinogenic and promoting action of a choline-devoid diet in the rat.
TLDR
The diets appear to act as complete carcinogens, since they are also efficient promoters of chemical hepatocarcinogenesis, as shown by the results obtained in the diethylnitrosamine-pretreated rats. Expand
Chloroform inhibits the development of diethylnitrosamine-initiated, phenobarbital-promoted gamma-glutamyltranspeptidase and placental form glutathione S-transferase-positive foci in rat liver.
TLDR
It is demonstrated that chloroform reduces the number of detectable preneoplastic enzyme-altered foci [gamma-glutamyltranspeptidase- positive (GGT+) and placental form glutathione S-transferase-positive (GST-P+)] in the liver of male Fischer 344 rats in a dose-dependent manner. Expand
Separation and quantitation of nitrobenzenes and their reduction products nitroanilines and phenylenediamines by reversed-phase high-performance liquid chromatography
Abstract A reversed-phase high-performance liquid chromatographic method for the separation and quantitation of a mixture consisting of nitrobenzene, dinitrobenzene isomers, 1,3,5-trinitrobenzene andExpand
Fourteen‐day Toxicity Study of 1,3,5‐Trinitrobenzene in Fischer 344 Rats
TLDR
Hematology and clinical chemistry studies indicated a decrease in red blood cell count and hematocrit, a decreases in alkaline phosphatase, an increase in Heinz bodies and increased methemoglobin concentration as compared to controls in both sexes. Expand
...
1
2
3
4
...