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Randomized, double‐blind placebo‐ and tolterodine‐controlled trial of the once‐daily antimuscarinic agent solifenacin in patients with symptomatic overactive bladder
An international, multicentre, randomized double‐blind trial is presented. Patients were randomized to treatment with tolterodine, placebo, and two doses of solifenacin. The authors concluded that… Expand
Efficacy and tolerability of mirabegron, a β(3)-adrenoceptor agonist, in patients with overactive bladder: results from a randomised European-Australian phase 3 trial.
BACKGROUND Mirabegron, a β(3)-adrenoceptor agonist, has been developed for the treatment of overactive bladder (OAB). OBJECTIVE To assess the efficacy and tolerability of mirabegron versus placebo.… Expand
Combination treatment with mirabegron and solifenacin in patients with overactive bladder: efficacy and safety results from a randomised, double-blind, dose-ranging, phase 2 study (Symphony).
BACKGROUND Combining the β3-adrenoceptor agonist mirabegron and the antimuscarinic (AM) agent solifenacin may improve efficacy in the treatment of overactive bladder (OAB) while reducing the AM side… Expand
Long-Term Outcomes of Elagolix in Women With Endometriosis: Results From Two Extension Studies.
OBJECTIVE To evaluate the efficacy and safety of elagolix, an oral, nonpeptide gonadotropin-releasing hormone antagonist, over 12 months in women with endometriosis-associated pain. METHODS Elaris… Expand
The clinical effectiveness of retropubic (IVS-02) and transobturator (IVS-04) midurethral slings: randomized trial.
- T. Rechberger, K. Futyma, K. Jankiewicz, A. Adamiak, P. Skorupski
- European urology
- 1 July 2009
BACKGROUND Few series comparing the clinical efficacy of retropubic slings versus transobturator slings for the treatment of female stress urinary incontinence (SUI) are available. OBJECTIVE To… Expand
Connective Tissue Changes in the Cervix During Normal Pregnancy and Pregnancy Complicated by Cervical Incompetence
When postpartum cervical biopsy specimens were compared with biopsy specimens from nonpregnant women, they revealed a 12-fold decrease in mechanical strength, a 50% reduction in the concentrations of… Expand
The efficacy and safety of mirabegron compared with solifenacin in overactive bladder patients dissatisfied with previous antimuscarinic treatment due to lack of efficacy: results of a…
Objective: To compare the efficacy and safety of mirabegron 50 mg and solifenacin 5 mg in overactive bladder (OAB) patients dissatisfied with previous antimuscarinic treatment due to lack of… Expand
The polymorphisms of the MMP-1 and the MMP-3 genes and the risk of pelvic organ prolapse
- P. Skorupski, K. Jankiewicz, P. Miotła, M. Marczak, B. Kulik-Rechberger, T. Rechberger
- International Urogynecology Journal
- 30 October 2012
Introduction and hypothesisTo investigate the associations between single nucleotide polymorphism (SNP) type 1G/2G at position −1607/−1608 of the matrix metalloproteinase (MMP)-1 gene and SNP type… Expand
OnabotulinumtoxinA improves health-related quality of life in patients with urinary incontinence due to idiopathic overactive bladder: a 36-week, double-blind, placebo-controlled, randomized,…
BACKGROUND Patients with urgency urinary incontinence (UUI) due to overactive bladder (OAB) refractory to oral antimuscarinics have limited therapeutic options. OnabotulinumtoxinA appears to be an… Expand
Prevalence of estrogen receptor alpha PvuII and XbaI polymorphism in population of Polish postmenopausal women.
- A. Jakimiuk, M. Nowicka, +5 authors J. Haczyński
- Medicine, Biology
- Folia histochemica et cytobiologica
Numerous data indicate that polymorphism of estrogen receptor alpha (ERalpha) may predict lipid levels, lipid response to hormone replacement therapy (HRT), myocardial infarction risk, bone fracture… Expand