Lysolecithin induces demyelination in vitro in a cerebellar slice culture system
Lysolecithin induces demyelination in an in vitro organotypic cerebellar slice culture system, providing a model system for studying myelination, demyelin basic protein, myelin oligodendrocyte glycoprotein, and MOG in vitro.
Microglial activation state and lysophospholipid acid receptor expression
Sphingosine 1-phosphate receptor agonists attenuate relapsing–remitting experimental autoimmune encephalitis in SJL mice
Characterization of lysophosphatidic acid and sphingosine‐1‐phosphate‐mediated signal transduction in rat cortical oligodendrocytes
The results taken together suggest that lysophospholipid receptor activation involves receptor coupling to heterotrimeric Gq subunits with consequent activation of PLC, PKC, and MAPK pathways leading to ERK phosphorylation.
Oxysterols are agonist ligands of RORγt and drive Th17 cell differentiation
- P. Soroosh, Jiejun Wu, Siquan Sun
- BiologyProceedings of the National Academy of Sciences
- 4 August 2014
Evidence is presented that 7β, 27-dihydroxycholesterol and 7α,27-OHC are RORγt agonist ligands and may serve as potential endogenous R ORγt ligands in promoting the differentiation of mouse and human CD4+ Th17 cells, and it is shown that Th17, but not Th1 cells, preferentially produce these two oxysterols.
Pharmacological characterization of lysophospholipid receptor signal transduction pathways in rat cerebrocortical astrocytes
(S)-(-)-5-ethynyl-3-(1-methyl-2-pyrrolidinyl)pyridine maleate (SIB-1508Y): a novel anti-parkinsonian agent with selectivity for neuronal nicotinic acetylcholine receptors.
Characterization of the recombinant human neuronal nicotinic acetylcholine receptors alpha3beta2 and alpha4beta2 stably expressed in HEK293 cells.
The results indicate that stably expressed alpha3beta2 and alpha4beta2 human nAChRs are pharmacologically and functionally distinct and that A3B2 cells are less sensitive to ACh than A4B2.2 cells.
Inhibition of Nitric Oxide Synthase Blocks N‐Methyl‐D‐Aspartate‐, Quisqualate‐, Kainate‐, Harmaline‐, and Pentylenetetrazole‐Dependent Increases in Cerebellar Cyclic GMP In Vivo
- P. Wood, M. Emmett, T. Rao, J. Cler, S. Mick, S. Iyengar
- Biology, ChemistryJournal of Neurochemistry
- 1 July 1990
The first in vivo demonstration that nitric oxide is an important “messenger molecule” in the cerebellum, mediating the actions of kainate, quisqualate, and N‐methyl‐D‐aspartate receptor agonists on guanylate cyclase is demonstrated.
KD5170, a novel mercaptoketone-based histone deacetylase inhibitor that exhibits broad spectrum antitumor activity in vitro and in vivo
The biological and pharmaceutical profile of KD5170 supports its continued preclinical and clinical development as a broad spectrum anticancer agent and shows significant antiproliferative activity against a variety of human tumor cell lines, including the NCI-60 panel.